Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats
Objective(s): This research aimed to test the impact of liver ischemia/reperfusion (IR) insult on the activity of antioxidant enzymes, functional enzymes, histological, and hemodynamic parameters of heart, as well as protective function of crocin on these variables in rats. Materials and Methods:...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2019-03-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_12165_bab763290401e0a9523978aca21297bf.pdf |
| _version_ | 1818149657347358720 |
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| author | Ghaidafeh Akbari Seyyed Ali Mard Mahin Dianat |
| author_facet | Ghaidafeh Akbari Seyyed Ali Mard Mahin Dianat |
| author_sort | Ghaidafeh Akbari |
| collection | DOAJ |
| description | Objective(s): This research aimed to test the impact of liver ischemia/reperfusion (IR) insult on the activity of antioxidant enzymes, functional enzymes, histological, and hemodynamic parameters of heart, as well as protective function of crocin on these variables in rats. Materials and Methods: Thirty two rats were randomly assigned into 4 experimental groups (8 rats in each). I: sham-operated, II: IR induction, III: Crocin alone, and IV: Crocin+IR induction. Groups I and III received normal saline at 2 ml per day and crocin at 200 mg per kg on a daily basis for a week via intraperitoneally injection. Afterwards, laparotomy was performed. Groups II and IV was also received normal saline and crocin and then experienced a 45 min ischemia followed by 1 hr reperfusion. Tissue samples of heart and blood were taken to use for further microscopic and laboratories analysis. Hemodynamic parameters were measured by tail cuff method. Results: Findings indicated that crocin dramatically elevated the activity of antioxidant enzymes, and attenuated serum concentrations of hepatic and cardiac enzymes. Crocin also inhibited histopathological disarrangements, and modulated hemodynamic parameters beyond IR-induced hepatic insult. Conclusion: Current experiment indicated that crocin has potential cardioprotective action following hepatic I/R-induced damage. Therefore, it can be administered before elective hepatic surgeries. |
| first_indexed | 2024-12-11T13:10:31Z |
| format | Article |
| id | doaj.art-512aa6559bf749be983c340ea27059ee |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-11T13:10:31Z |
| publishDate | 2019-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-512aa6559bf749be983c340ea27059ee2022-12-22T01:06:12ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742019-03-0122327728110.22038/ijbms.2019.29660.715912165Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in ratsGhaidafeh Akbari0Seyyed Ali Mard1Mahin Dianat2Department of Physiology, Yasuj University of Medical Sciences, Yasuj, IranAlimentary Tract Research Center, Physiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranPhysiology Research Center, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranObjective(s): This research aimed to test the impact of liver ischemia/reperfusion (IR) insult on the activity of antioxidant enzymes, functional enzymes, histological, and hemodynamic parameters of heart, as well as protective function of crocin on these variables in rats. Materials and Methods: Thirty two rats were randomly assigned into 4 experimental groups (8 rats in each). I: sham-operated, II: IR induction, III: Crocin alone, and IV: Crocin+IR induction. Groups I and III received normal saline at 2 ml per day and crocin at 200 mg per kg on a daily basis for a week via intraperitoneally injection. Afterwards, laparotomy was performed. Groups II and IV was also received normal saline and crocin and then experienced a 45 min ischemia followed by 1 hr reperfusion. Tissue samples of heart and blood were taken to use for further microscopic and laboratories analysis. Hemodynamic parameters were measured by tail cuff method. Results: Findings indicated that crocin dramatically elevated the activity of antioxidant enzymes, and attenuated serum concentrations of hepatic and cardiac enzymes. Crocin also inhibited histopathological disarrangements, and modulated hemodynamic parameters beyond IR-induced hepatic insult. Conclusion: Current experiment indicated that crocin has potential cardioprotective action following hepatic I/R-induced damage. Therefore, it can be administered before elective hepatic surgeries.http://ijbms.mums.ac.ir/article_12165_bab763290401e0a9523978aca21297bf.pdfCrocinHeartHemodynamic parametersIschemia/ReperfusionLiver |
| spellingShingle | Ghaidafeh Akbari Seyyed Ali Mard Mahin Dianat Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats Iranian Journal of Basic Medical Sciences Crocin Heart Hemodynamic parameters Ischemia/Reperfusion Liver |
| title | Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats |
| title_full | Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats |
| title_fullStr | Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats |
| title_full_unstemmed | Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats |
| title_short | Effect of crocin on cardiac antioxidants, and hemodynamic parameters after injuries induced by hepatic ischemia-reperfusion in rats |
| title_sort | effect of crocin on cardiac antioxidants and hemodynamic parameters after injuries induced by hepatic ischemia reperfusion in rats |
| topic | Crocin Heart Hemodynamic parameters Ischemia/Reperfusion Liver |
| url | http://ijbms.mums.ac.ir/article_12165_bab763290401e0a9523978aca21297bf.pdf |
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