Can the type of subjective response to first opioid exposure predict the risk of opioid use disorder? A scoping review
Background: Effective identification of individuals at increased risk for developing opioid use disorder (OUD) could reduce the overdose fatalities and mitigate the harm of the opioid epidemic. Early evidence has linked certain subjective experiences during the first substance exposure to subsequent...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923022001836 |
| _version_ | 1827391937288601600 |
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| author | Christian J. Morris Sara Mills-Huffnagle Aleksandra E. Zgierska |
| author_facet | Christian J. Morris Sara Mills-Huffnagle Aleksandra E. Zgierska |
| author_sort | Christian J. Morris |
| collection | DOAJ |
| description | Background: Effective identification of individuals at increased risk for developing opioid use disorder (OUD) could reduce the overdose fatalities and mitigate the harm of the opioid epidemic. Early evidence has linked certain subjective experiences during the first substance exposure to subsequent substance misuse. This is consistent with anecdotal evidence that “first response” to opioids may distinguish those who later develop OUD from those who do not, further suggesting individual differences in neural activity and responses to specific substances. Objective: The objective of this scoping review was to evaluate the evidence on the relationship between the subjective first response to opioids and the risk of developing OUD. Methods: Ovid MEDLINE search (through 1/29/2021), followed by the search for articles published by the first/senior authors (PubMed) and references citing (Web of Science Citing Reference) identified eligible publications, was focused on studies involving humans, published in English, and describing the initial subjective response to opioid exposure and its association with OUD development or its risk. Systematic data extraction was completed for each eligible study. Results: 3364 title/abstracts and 48 full-text articles were reviewed. Four articles, describing six studies (526 adult participants) were eligible and included. These studies were methodologically heterogeneous, including 2 randomized controlled trials, and 1 case-control, and 3 cross-sectional studies, with small sample sizes, precluding data pooling and meta-analysis. Results suggested that individuals with OUD or at elevated risk for OUD (determined by the validated OUD risk assessment surveys) were more likely to report their “first opioid response” as euphoric compared to their counterparts. Conclusions: Limited evidence suggests that subjectively-reported euphoric response to first opioid exposure could predict the OUD risk. Prospective studies are needed to evaluate the utility of assessing first response (e.g., via brief point-of-care screening surveys) for informing clinical decisions when prescribing opioids. |
| first_indexed | 2024-03-08T17:22:37Z |
| format | Article |
| id | doaj.art-512c0b5955284b7487c30d08dc563eba |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-08T17:22:37Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-512c0b5955284b7487c30d08dc563eba2024-01-03T04:11:56ZengElsevierBrain Research Bulletin1873-27472022-10-011886776Can the type of subjective response to first opioid exposure predict the risk of opioid use disorder? A scoping reviewChristian J. Morris0Sara Mills-Huffnagle1Aleksandra E. Zgierska2Penn State College of Medicine, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USAPenn State College of Medicine, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USAPenn State College of Medicine, Departments of Family and Community Medicine, Anesthesiology and Perioperative Medicine, and Public Health Sciences, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA; Correspondence to: 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA.Background: Effective identification of individuals at increased risk for developing opioid use disorder (OUD) could reduce the overdose fatalities and mitigate the harm of the opioid epidemic. Early evidence has linked certain subjective experiences during the first substance exposure to subsequent substance misuse. This is consistent with anecdotal evidence that “first response” to opioids may distinguish those who later develop OUD from those who do not, further suggesting individual differences in neural activity and responses to specific substances. Objective: The objective of this scoping review was to evaluate the evidence on the relationship between the subjective first response to opioids and the risk of developing OUD. Methods: Ovid MEDLINE search (through 1/29/2021), followed by the search for articles published by the first/senior authors (PubMed) and references citing (Web of Science Citing Reference) identified eligible publications, was focused on studies involving humans, published in English, and describing the initial subjective response to opioid exposure and its association with OUD development or its risk. Systematic data extraction was completed for each eligible study. Results: 3364 title/abstracts and 48 full-text articles were reviewed. Four articles, describing six studies (526 adult participants) were eligible and included. These studies were methodologically heterogeneous, including 2 randomized controlled trials, and 1 case-control, and 3 cross-sectional studies, with small sample sizes, precluding data pooling and meta-analysis. Results suggested that individuals with OUD or at elevated risk for OUD (determined by the validated OUD risk assessment surveys) were more likely to report their “first opioid response” as euphoric compared to their counterparts. Conclusions: Limited evidence suggests that subjectively-reported euphoric response to first opioid exposure could predict the OUD risk. Prospective studies are needed to evaluate the utility of assessing first response (e.g., via brief point-of-care screening surveys) for informing clinical decisions when prescribing opioids.http://www.sciencedirect.com/science/article/pii/S0361923022001836Opioid use disorderOpioid addictionAddiction screeningOpioids |
| spellingShingle | Christian J. Morris Sara Mills-Huffnagle Aleksandra E. Zgierska Can the type of subjective response to first opioid exposure predict the risk of opioid use disorder? A scoping review Brain Research Bulletin Opioid use disorder Opioid addiction Addiction screening Opioids |
| title | Can the type of subjective response to first opioid exposure predict the risk of opioid use disorder? A scoping review |
| title_full | Can the type of subjective response to first opioid exposure predict the risk of opioid use disorder? A scoping review |
| title_fullStr | Can the type of subjective response to first opioid exposure predict the risk of opioid use disorder? A scoping review |
| title_full_unstemmed | Can the type of subjective response to first opioid exposure predict the risk of opioid use disorder? A scoping review |
| title_short | Can the type of subjective response to first opioid exposure predict the risk of opioid use disorder? A scoping review |
| title_sort | can the type of subjective response to first opioid exposure predict the risk of opioid use disorder a scoping review |
| topic | Opioid use disorder Opioid addiction Addiction screening Opioids |
| url | http://www.sciencedirect.com/science/article/pii/S0361923022001836 |
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