Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer
<p>Abstract</p> <p>Background</p> <p>The nuclear factor-κB (NF-κB) family is a set of transcription factors with key roles in the induction of the inflammatory response and may be the link between inflammation and cancer development. This pathway has been shown to influ...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2009-06-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/9/170 |
| _version_ | 1818758616854822912 |
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| author | Kelemen Linda E Cunningham Julie M Schildkraut Joellen M Knutson Keith L Anderson Stephanie Fridley Brooke L Phelan Catherine M Vierkant Robert A White Kristin L Pankratz V Shane Rider David N Liebow Mark Hartmann Lynn C Sellers Thomas A Goode Ellen L |
| author_facet | Kelemen Linda E Cunningham Julie M Schildkraut Joellen M Knutson Keith L Anderson Stephanie Fridley Brooke L Phelan Catherine M Vierkant Robert A White Kristin L Pankratz V Shane Rider David N Liebow Mark Hartmann Lynn C Sellers Thomas A Goode Ellen L |
| author_sort | Kelemen Linda E |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The nuclear factor-κB (NF-κB) family is a set of transcription factors with key roles in the induction of the inflammatory response and may be the link between inflammation and cancer development. This pathway has been shown to influence ovarian epithelial tissue repair. Inhibitors of κB (IκB) prevent NF-κB activation by sequestering NF-κB proteins in the cytoplasm until IκB proteins are phosphorylated and degraded.</p> <p>Methods</p> <p>We used a case-control study to evaluate the association between single nucleotide polymorphisms (SNPs) in <it>NFKBIA </it>and <it>NFKBIB </it>(the genes encoding IκBα and IκBβ, respectively) and risk of epithelial ovarian cancer. We queried 19 tagSNPs and putative-functional SNPs among 930 epithelial ovarian cancer cases and 1,037 controls from two studies.</p> <p>Results</p> <p>The minor allele for one synonymous SNP in <it>NFKBIA</it>, rs1957106, was associated with decreased risk (p = 0.03).</p> <p>Conclusion</p> <p>Considering the number of single-SNP tests performed and null gene-level results, we conclude that <it>NFKBIA </it>and <it>NFKBIB </it>are not likely to harbor ovarian cancer risk alleles. Due to its biological significance in ovarian cancer, additional genes encoding NF-κB subunits, activating and inhibiting molecules, and signaling molecules warrant interrogation.</p> |
| first_indexed | 2024-12-18T06:29:40Z |
| format | Article |
| id | doaj.art-512d3599137e48cba1f68b906585be27 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-18T06:29:40Z |
| publishDate | 2009-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-512d3599137e48cba1f68b906585be272022-12-21T21:17:56ZengBMCBMC Cancer1471-24072009-06-019117010.1186/1471-2407-9-170Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian CancerKelemen Linda ECunningham Julie MSchildkraut Joellen MKnutson Keith LAnderson StephanieFridley Brooke LPhelan Catherine MVierkant Robert AWhite Kristin LPankratz V ShaneRider David NLiebow MarkHartmann Lynn CSellers Thomas AGoode Ellen L<p>Abstract</p> <p>Background</p> <p>The nuclear factor-κB (NF-κB) family is a set of transcription factors with key roles in the induction of the inflammatory response and may be the link between inflammation and cancer development. This pathway has been shown to influence ovarian epithelial tissue repair. Inhibitors of κB (IκB) prevent NF-κB activation by sequestering NF-κB proteins in the cytoplasm until IκB proteins are phosphorylated and degraded.</p> <p>Methods</p> <p>We used a case-control study to evaluate the association between single nucleotide polymorphisms (SNPs) in <it>NFKBIA </it>and <it>NFKBIB </it>(the genes encoding IκBα and IκBβ, respectively) and risk of epithelial ovarian cancer. We queried 19 tagSNPs and putative-functional SNPs among 930 epithelial ovarian cancer cases and 1,037 controls from two studies.</p> <p>Results</p> <p>The minor allele for one synonymous SNP in <it>NFKBIA</it>, rs1957106, was associated with decreased risk (p = 0.03).</p> <p>Conclusion</p> <p>Considering the number of single-SNP tests performed and null gene-level results, we conclude that <it>NFKBIA </it>and <it>NFKBIB </it>are not likely to harbor ovarian cancer risk alleles. Due to its biological significance in ovarian cancer, additional genes encoding NF-κB subunits, activating and inhibiting molecules, and signaling molecules warrant interrogation.</p>http://www.biomedcentral.com/1471-2407/9/170 |
| spellingShingle | Kelemen Linda E Cunningham Julie M Schildkraut Joellen M Knutson Keith L Anderson Stephanie Fridley Brooke L Phelan Catherine M Vierkant Robert A White Kristin L Pankratz V Shane Rider David N Liebow Mark Hartmann Lynn C Sellers Thomas A Goode Ellen L Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer BMC Cancer |
| title | Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer |
| title_full | Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer |
| title_fullStr | Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer |
| title_full_unstemmed | Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer |
| title_short | Polymorphisms in NF-κB Inhibitors and Risk of Epithelial Ovarian Cancer |
| title_sort | polymorphisms in nf κb inhibitors and risk of epithelial ovarian cancer |
| url | http://www.biomedcentral.com/1471-2407/9/170 |
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