Circ_0003945: an emerging biomarker and therapeutic target for human diseases
Due to the rapid development of RNA sequencing techniques, a circular non-coding RNA (ncRNA) known as circular RNAs (circRNAs) has gradually come into focus. As a distinguished member of the circRNA family, circ_0003945 has garnered attention for its aberrant expression and biochemical functions in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1275009/full |
| _version_ | 1797198710961078272 |
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| author | Xiaofei Zhang Li Ma Li Wan Haoran Wang Zhaoxia Wang |
| author_facet | Xiaofei Zhang Li Ma Li Wan Haoran Wang Zhaoxia Wang |
| author_sort | Xiaofei Zhang |
| collection | DOAJ |
| description | Due to the rapid development of RNA sequencing techniques, a circular non-coding RNA (ncRNA) known as circular RNAs (circRNAs) has gradually come into focus. As a distinguished member of the circRNA family, circ_0003945 has garnered attention for its aberrant expression and biochemical functions in human diseases. Subsequent studies have revealed that circ_0003945 could regulate tumor cells proliferation, migration, invasion, apoptosis, autophagy, angiogenesis, drug resistance, and radio resistance through the molecular mechanism of competitive endogenous RNA (ceRNA) during tumorigenesis. The expression of circ_0003945 is frequently associated with some clinical parameters and implies a poorer prognosis in the majority of cancers. In non-malignant conditions, circ_0003945 also holds considerable importance in diseases pathogenesis. This review aims to recapitulate molecular mechanism of circ_0003945 and elucidates its potential as a diagnostic and therapeutic target in neoplasms and other diseases. |
| first_indexed | 2024-04-24T07:04:12Z |
| format | Article |
| id | doaj.art-512dd08aaaf846aba31155f0f5cab0b6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-24T07:04:12Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-512dd08aaaf846aba31155f0f5cab0b62024-04-22T05:09:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-04-011410.3389/fonc.2024.12750091275009Circ_0003945: an emerging biomarker and therapeutic target for human diseasesXiaofei Zhang0Li Ma1Li Wan2Haoran Wang3Zhaoxia Wang4Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaCancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Oncology, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, ChinaDivision of Spine Surgery, Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, ChinaCancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDue to the rapid development of RNA sequencing techniques, a circular non-coding RNA (ncRNA) known as circular RNAs (circRNAs) has gradually come into focus. As a distinguished member of the circRNA family, circ_0003945 has garnered attention for its aberrant expression and biochemical functions in human diseases. Subsequent studies have revealed that circ_0003945 could regulate tumor cells proliferation, migration, invasion, apoptosis, autophagy, angiogenesis, drug resistance, and radio resistance through the molecular mechanism of competitive endogenous RNA (ceRNA) during tumorigenesis. The expression of circ_0003945 is frequently associated with some clinical parameters and implies a poorer prognosis in the majority of cancers. In non-malignant conditions, circ_0003945 also holds considerable importance in diseases pathogenesis. This review aims to recapitulate molecular mechanism of circ_0003945 and elucidates its potential as a diagnostic and therapeutic target in neoplasms and other diseases.https://www.frontiersin.org/articles/10.3389/fonc.2024.1275009/fullcancercirc_0003945ceRNAbiomarkertherapeutic target |
| spellingShingle | Xiaofei Zhang Li Ma Li Wan Haoran Wang Zhaoxia Wang Circ_0003945: an emerging biomarker and therapeutic target for human diseases Frontiers in Oncology cancer circ_0003945 ceRNA biomarker therapeutic target |
| title | Circ_0003945: an emerging biomarker and therapeutic target for human diseases |
| title_full | Circ_0003945: an emerging biomarker and therapeutic target for human diseases |
| title_fullStr | Circ_0003945: an emerging biomarker and therapeutic target for human diseases |
| title_full_unstemmed | Circ_0003945: an emerging biomarker and therapeutic target for human diseases |
| title_short | Circ_0003945: an emerging biomarker and therapeutic target for human diseases |
| title_sort | circ 0003945 an emerging biomarker and therapeutic target for human diseases |
| topic | cancer circ_0003945 ceRNA biomarker therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1275009/full |
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