Influence of Metabolic Syndrome on Small, Dense LDL, and Subclinical Atherosclerosis in Older Subjects
Aging is known as one of the important risk factors for coronary artery disease (CAD). We explore whether an association of metabolic syndrome (Met- S ) increases subclinical atherosclerosis among elderly diabetic subjects estimating the plaque score ( PS ) of the carotid artery. A total of 187 subj...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-06-01
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| Series: | Gerontology and Geriatric Medicine |
| Online Access: | https://doi.org/10.1177/23337214231179847 |
| _version_ | 1797807105529348096 |
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| author | Hiroshi Yoshino MD, PhD Tomoko Matsumoto MD, PhD Gen Yoshino MD, PhD |
| author_facet | Hiroshi Yoshino MD, PhD Tomoko Matsumoto MD, PhD Gen Yoshino MD, PhD |
| author_sort | Hiroshi Yoshino MD, PhD |
| collection | DOAJ |
| description | Aging is known as one of the important risk factors for coronary artery disease (CAD). We explore whether an association of metabolic syndrome (Met- S ) increases subclinical atherosclerosis among elderly diabetic subjects estimating the plaque score ( PS ) of the carotid artery. A total of 187 subjects were enrolled. Middle-aged and older groups were divided into two groups. T -test and Chi-square test were also employed. Simple regression analysis for the PS was performed with respective risk factors as independent variables. After selection of independent variables, multiple regression analysis was performed to estimated the association of PS and dependent variable of the study. There were significant differences in body mass index (BMI) ( p < .001), HbA1c ( p < .01), TG ( p < .05), and PS ( p < .001) . Multiple regression analysis in middle-aged subjects showed that the determinant of PS were age ( p < .001), BMI ( p = .006), Met- S ( p = .004), and hs-CRP ( p = .019). Multiple regression analysis in older subjects showed that neither age nor Met- S was included as significant determinant of PS . An association of Met- S is an important factor for progression of subclinical atherosclerosis, but it cannot be a significant determinant of PS if the subjects are limited within older group. |
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| format | Article |
| id | doaj.art-512e42907f06436baf1edb1e47a2d26d |
| institution | Directory Open Access Journal |
| issn | 2333-7214 |
| language | English |
| last_indexed | 2024-03-13T06:17:32Z |
| publishDate | 2023-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Gerontology and Geriatric Medicine |
| spelling | doaj.art-512e42907f06436baf1edb1e47a2d26d2023-06-10T05:03:23ZengSAGE PublishingGerontology and Geriatric Medicine2333-72142023-06-01910.1177/23337214231179847Influence of Metabolic Syndrome on Small, Dense LDL, and Subclinical Atherosclerosis in Older SubjectsHiroshi Yoshino MD, PhD0Tomoko Matsumoto MD, PhD1Gen Yoshino MD, PhD2Fujita Health University School of Medicine, Toyoake, JapanToyo-do clinic, Tokyo, JapanShinsuma General Hospital, Kobe, JapanAging is known as one of the important risk factors for coronary artery disease (CAD). We explore whether an association of metabolic syndrome (Met- S ) increases subclinical atherosclerosis among elderly diabetic subjects estimating the plaque score ( PS ) of the carotid artery. A total of 187 subjects were enrolled. Middle-aged and older groups were divided into two groups. T -test and Chi-square test were also employed. Simple regression analysis for the PS was performed with respective risk factors as independent variables. After selection of independent variables, multiple regression analysis was performed to estimated the association of PS and dependent variable of the study. There were significant differences in body mass index (BMI) ( p < .001), HbA1c ( p < .01), TG ( p < .05), and PS ( p < .001) . Multiple regression analysis in middle-aged subjects showed that the determinant of PS were age ( p < .001), BMI ( p = .006), Met- S ( p = .004), and hs-CRP ( p = .019). Multiple regression analysis in older subjects showed that neither age nor Met- S was included as significant determinant of PS . An association of Met- S is an important factor for progression of subclinical atherosclerosis, but it cannot be a significant determinant of PS if the subjects are limited within older group.https://doi.org/10.1177/23337214231179847 |
| spellingShingle | Hiroshi Yoshino MD, PhD Tomoko Matsumoto MD, PhD Gen Yoshino MD, PhD Influence of Metabolic Syndrome on Small, Dense LDL, and Subclinical Atherosclerosis in Older Subjects Gerontology and Geriatric Medicine |
| title | Influence of Metabolic Syndrome on Small, Dense LDL, and Subclinical Atherosclerosis in Older Subjects |
| title_full | Influence of Metabolic Syndrome on Small, Dense LDL, and Subclinical Atherosclerosis in Older Subjects |
| title_fullStr | Influence of Metabolic Syndrome on Small, Dense LDL, and Subclinical Atherosclerosis in Older Subjects |
| title_full_unstemmed | Influence of Metabolic Syndrome on Small, Dense LDL, and Subclinical Atherosclerosis in Older Subjects |
| title_short | Influence of Metabolic Syndrome on Small, Dense LDL, and Subclinical Atherosclerosis in Older Subjects |
| title_sort | influence of metabolic syndrome on small dense ldl and subclinical atherosclerosis in older subjects |
| url | https://doi.org/10.1177/23337214231179847 |
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