High mupirocin susceptibility in isolates of Sta-phylococcus aureus colonizing hemodialysis pa-tients in a dialysis unit at Medellín
Objective: To describe the resistance percentage to mupirocin and other antibiotics in Staphylococcus aureus isolates colonizing hemodialysis patients. Methods: A descriptive study was conducted at an outpatient dialysis center in Medellín and hemodialy-sis patients with catheter...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Antioquia
2021-04-01
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| Series: | Iatreia |
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| Online Access: | https://revistas.udea.edu.co/index.php/iatreia/article/view/341010/20802945 |
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| author | Torres-Cuadros, Yesid Leandro Vélez-Montoya, Juan Guillermo Vanegas-Munera, Johanna Marcela Roncancio-Villamil, Gustavo Eduardo Jiménez-Quiceno, Judy Natalia |
| author_facet | Torres-Cuadros, Yesid Leandro Vélez-Montoya, Juan Guillermo Vanegas-Munera, Johanna Marcela Roncancio-Villamil, Gustavo Eduardo Jiménez-Quiceno, Judy Natalia |
| author_sort | Torres-Cuadros, Yesid Leandro |
| collection | DOAJ |
| description | Objective: To describe the resistance percentage to mupirocin and other antibiotics in Staphylococcus aureus isolates colonizing hemodialysis patients.
Methods: A descriptive study was conducted at an outpatient dialysis center in Medellín and hemodialy-sis patients with catheter were included. Colonization by S. aureus was evaluated in nostrils and skin. Bacterial identification was performed by PCR and an-tibiotic susceptibility was determined by the Vitek-2 automated system and by E-test. Clinical information was obtained from medical records.
Results: Two hundred and ten patients were included, of which 50.5% (n=106) were women, with a median for the age of 62 years (IQR 51,87-71,13). Among the cli-nical characteristics, the frequent use of antibiotics 59% (n=124) and the history of hospitalization 69% (n=145) were highlighted. The percentage of colonization by S. aureus was 33.8% (n=71) and the most frequent site of colonization was nostrils (19%; n=40). All isolates were susceptible to mupirocin by the method of Vitek-2. However, one isolate showed low level resistance to mupirocin by E-test. Colonization by methicillin-resis-tant isolates (MRSA) was 4.8% (n=10); which presented mainly resistance only to oxacillin (58,3%; n = 7).
Conclusion: The high susceptibility to mupirocin in isolates of colonizing S. aureus suggests its use as prophylactic therapy in hemodialysis patients with high risk of infection. It is important to strengthen programs for the rational use of antibiotics to prevent the spread of mechanisms of resistance to this and other antibiotics at dialysis units. |
| first_indexed | 2024-12-22T13:20:05Z |
| format | Article |
| id | doaj.art-51331920f6e94310902bee91e12ace94 |
| institution | Directory Open Access Journal |
| issn | 0121-0793 2011-7965 |
| language | Spanish |
| last_indexed | 2024-12-22T13:20:05Z |
| publishDate | 2021-04-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Iatreia |
| spelling | doaj.art-51331920f6e94310902bee91e12ace942022-12-21T18:24:29ZspaUniversidad de AntioquiaIatreia0121-07932011-79652021-04-013429710610.17533/udea.iatreia.71High mupirocin susceptibility in isolates of Sta-phylococcus aureus colonizing hemodialysis pa-tients in a dialysis unit at MedellínTorres-Cuadros, Yesid Leandro0https://orcid.org/0000-0002-1567-4476Vélez-Montoya, Juan Guillermo1https://orcid.org/0000-0001-7567-3574Vanegas-Munera, Johanna Marcela2https://orcid.org/0000-0003-0649-6660Roncancio-Villamil, Gustavo Eduardo3https://orcid.org/0000-0002-2677-6398Jiménez-Quiceno, Judy Natalia4https://orcid.org/0000-0002-9183-1912Universidad de AntioquiaUniversidad de AntioquiaUniversidad de AntioquiaClínica CardioVidUniversidad de AntioquiaObjective: To describe the resistance percentage to mupirocin and other antibiotics in Staphylococcus aureus isolates colonizing hemodialysis patients. Methods: A descriptive study was conducted at an outpatient dialysis center in Medellín and hemodialy-sis patients with catheter were included. Colonization by S. aureus was evaluated in nostrils and skin. Bacterial identification was performed by PCR and an-tibiotic susceptibility was determined by the Vitek-2 automated system and by E-test. Clinical information was obtained from medical records. Results: Two hundred and ten patients were included, of which 50.5% (n=106) were women, with a median for the age of 62 years (IQR 51,87-71,13). Among the cli-nical characteristics, the frequent use of antibiotics 59% (n=124) and the history of hospitalization 69% (n=145) were highlighted. The percentage of colonization by S. aureus was 33.8% (n=71) and the most frequent site of colonization was nostrils (19%; n=40). All isolates were susceptible to mupirocin by the method of Vitek-2. However, one isolate showed low level resistance to mupirocin by E-test. Colonization by methicillin-resis-tant isolates (MRSA) was 4.8% (n=10); which presented mainly resistance only to oxacillin (58,3%; n = 7). Conclusion: The high susceptibility to mupirocin in isolates of colonizing S. aureus suggests its use as prophylactic therapy in hemodialysis patients with high risk of infection. It is important to strengthen programs for the rational use of antibiotics to prevent the spread of mechanisms of resistance to this and other antibiotics at dialysis units.https://revistas.udea.edu.co/index.php/iatreia/article/view/341010/20802945dialysismupirocinstaphylococcus aureus |
| spellingShingle | Torres-Cuadros, Yesid Leandro Vélez-Montoya, Juan Guillermo Vanegas-Munera, Johanna Marcela Roncancio-Villamil, Gustavo Eduardo Jiménez-Quiceno, Judy Natalia High mupirocin susceptibility in isolates of Sta-phylococcus aureus colonizing hemodialysis pa-tients in a dialysis unit at Medellín Iatreia dialysis mupirocin staphylococcus aureus |
| title | High mupirocin susceptibility in isolates of Sta-phylococcus aureus colonizing hemodialysis pa-tients in a dialysis unit at Medellín |
| title_full | High mupirocin susceptibility in isolates of Sta-phylococcus aureus colonizing hemodialysis pa-tients in a dialysis unit at Medellín |
| title_fullStr | High mupirocin susceptibility in isolates of Sta-phylococcus aureus colonizing hemodialysis pa-tients in a dialysis unit at Medellín |
| title_full_unstemmed | High mupirocin susceptibility in isolates of Sta-phylococcus aureus colonizing hemodialysis pa-tients in a dialysis unit at Medellín |
| title_short | High mupirocin susceptibility in isolates of Sta-phylococcus aureus colonizing hemodialysis pa-tients in a dialysis unit at Medellín |
| title_sort | high mupirocin susceptibility in isolates of sta phylococcus aureus colonizing hemodialysis pa tients in a dialysis unit at medellin |
| topic | dialysis mupirocin staphylococcus aureus |
| url | https://revistas.udea.edu.co/index.php/iatreia/article/view/341010/20802945 |
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