Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro

Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro

Abstract Background Various types of normal and cancer cells undergo senescence in response to carboplatin and paclitaxel, which are considered the gold standard treatments in ovarian cancer management. Surprisingly, the effect of these drugs on ovarian cancer cell senescence remained unknown. Metho...

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Main Authors: Paweł Uruski, Agnieszka Sepetowska, Corinna Konieczna, Martyna Pakuła, Michał Wyrwa, Akylbek Tussupkaliyev, Andrzej Tykarski, Justyna Mikuła-Pietrasik, Krzysztof Książek
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Cellular & Molecular Biology Letters
Subjects:
Cellular senescence
Drug-induced senescence
Ovarian cancer
Senescence-associated secretory phenotype
Online Access:https://doi.org/10.1186/s11658-021-00287-4

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