An Outcome Analysis of Asymptomatic COVID-19 Patients Presenting with Angina- A Retrospective Study
Introduction: Cardiovascular disorders have long been considered as one of the leading causes of mortality in India, which when presented with concurrent Coronavirus Disease (COVID-19) infection becomes even more fatal. Evidence suggests that COVID-19 affects the cardiovascular system by causing exu...
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| Format: | Article |
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JCDR Research and Publications Private Limited
2023-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/17577/59103_CE[Ra1]_F(IS)_PF1_(KA_SS)_PFA(KA_KM)_PN(KM).pdf |
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| author | Dipankar Ghosh Dastidar Rakhi Sanyal Nandita Ghosh Dastidar Tirna Halder |
| author_facet | Dipankar Ghosh Dastidar Rakhi Sanyal Nandita Ghosh Dastidar Tirna Halder |
| author_sort | Dipankar Ghosh Dastidar |
| collection | DOAJ |
| description | Introduction: Cardiovascular disorders have long been considered as one of the leading causes of mortality in India, which when presented with concurrent Coronavirus Disease (COVID-19) infection becomes even more fatal. Evidence suggests that COVID-19 affects the cardiovascular system by causing exuberant cytokinaemia, which results in endothelial inflammation and microvascular thrombosis, leading to multiorgan failure.
Aim: To analyse the outcome of the asymptomatic COVID-19 patients presenting with cardiac angina during the second wave of COVID-19 in India.
Materials and Methods: This is a retrospective data analysis of asymptomatic COVID-19 patients hospitalised with angina was conducted between April 2021 to June 2021 at Bardhhaman Medical College and Hospital located at Bardhdhaman district of West Bengal, India. A total of 1235 patients underwent all regular biochemical, haematological and cardiac investigations after undergoing test for COVID-19 test. Data was retrospectively collected. The outcome of these patients was analysed. Estimation of mean, standard deviation, percentage, p-value (from Pearson’s correlation) was performed to establish the aim of the study.
Results: Seventy six out of 1235 patients tested positive for asymptomatic COVID-19. The mean age of this study population was 55.075±10.95 years, of which were 55 male and 21 female. Hypertension was the most prevalent co-morbidity followed by diabetes, 73 (96%) presented with chest pain. A total of 47(62%) of these 76 patients had ST Elevated Myocardial Infarction (STEMI). Eleven (14.4%) underwent Percutaneous Coronary Intervention (PCI) whereas 36 (47.3%) underwent fibrinolytic therapy with tenecteplase, followed by secondary PCI in 27 (75%) of them. Rest 29 (38%) were medically managed for unstable angina. Mortality rate was as low as 6.5%. Age and comorbidity were the contributing factors for STEMI among asymptomatic COVID-19 patients.
Conclusion: The results indicate that age and comorbidity are the factors, which lead to death or increases the life risk among patients with asymptomatic COVID-19. In this study, we have established that for the current patient population STEMI and age are negatively corelated. Medical management with thrombolytic agent became a lot more accepted in this scenario. PCI still remains the gold standard to treat myocardial infarction. It is recommended that there should be an ICMR guided protocol for the management of such cases with the concurrent COVID-19. |
| first_indexed | 2024-04-09T23:36:06Z |
| format | Article |
| id | doaj.art-5137e31adf174d6ba2b72ab2f3869001 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-09T23:36:06Z |
| publishDate | 2023-03-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-5137e31adf174d6ba2b72ab2f38690012023-03-20T07:02:46ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-03-01173OC01OC0410.7860/JCDR/2023/59103.17577An Outcome Analysis of Asymptomatic COVID-19 Patients Presenting with Angina- A Retrospective StudyDipankar Ghosh Dastidar0Rakhi Sanyal1Nandita Ghosh Dastidar2Tirna Halder3Associate Professor, Department of Cardiology, Burdwan Medical College, Kolkata, West Bengal, India.Associate Professor, Department of Internal Medicine, JIMSH, Kolkata, West Bengal, India.Consultant, Department of Pulmonology, South Eastern Railway Hospital, Kolkata, West Bengal, India.Director, Department of Clinical Operations, OrciVita Sciences and Research Pvt. Ltd., Kolkata, West Bengal, India.Introduction: Cardiovascular disorders have long been considered as one of the leading causes of mortality in India, which when presented with concurrent Coronavirus Disease (COVID-19) infection becomes even more fatal. Evidence suggests that COVID-19 affects the cardiovascular system by causing exuberant cytokinaemia, which results in endothelial inflammation and microvascular thrombosis, leading to multiorgan failure. Aim: To analyse the outcome of the asymptomatic COVID-19 patients presenting with cardiac angina during the second wave of COVID-19 in India. Materials and Methods: This is a retrospective data analysis of asymptomatic COVID-19 patients hospitalised with angina was conducted between April 2021 to June 2021 at Bardhhaman Medical College and Hospital located at Bardhdhaman district of West Bengal, India. A total of 1235 patients underwent all regular biochemical, haematological and cardiac investigations after undergoing test for COVID-19 test. Data was retrospectively collected. The outcome of these patients was analysed. Estimation of mean, standard deviation, percentage, p-value (from Pearson’s correlation) was performed to establish the aim of the study. Results: Seventy six out of 1235 patients tested positive for asymptomatic COVID-19. The mean age of this study population was 55.075±10.95 years, of which were 55 male and 21 female. Hypertension was the most prevalent co-morbidity followed by diabetes, 73 (96%) presented with chest pain. A total of 47(62%) of these 76 patients had ST Elevated Myocardial Infarction (STEMI). Eleven (14.4%) underwent Percutaneous Coronary Intervention (PCI) whereas 36 (47.3%) underwent fibrinolytic therapy with tenecteplase, followed by secondary PCI in 27 (75%) of them. Rest 29 (38%) were medically managed for unstable angina. Mortality rate was as low as 6.5%. Age and comorbidity were the contributing factors for STEMI among asymptomatic COVID-19 patients. Conclusion: The results indicate that age and comorbidity are the factors, which lead to death or increases the life risk among patients with asymptomatic COVID-19. In this study, we have established that for the current patient population STEMI and age are negatively corelated. Medical management with thrombolytic agent became a lot more accepted in this scenario. PCI still remains the gold standard to treat myocardial infarction. It is recommended that there should be an ICMR guided protocol for the management of such cases with the concurrent COVID-19.https://jcdr.net/articles/PDF/17577/59103_CE[Ra1]_F(IS)_PF1_(KA_SS)_PFA(KA_KM)_PN(KM).pdfcardiovascular diseasesmyocardial infarctionthrombolysis |
| spellingShingle | Dipankar Ghosh Dastidar Rakhi Sanyal Nandita Ghosh Dastidar Tirna Halder An Outcome Analysis of Asymptomatic COVID-19 Patients Presenting with Angina- A Retrospective Study Journal of Clinical and Diagnostic Research cardiovascular diseases myocardial infarction thrombolysis |
| title | An Outcome Analysis of Asymptomatic COVID-19 Patients Presenting with Angina- A Retrospective Study |
| title_full | An Outcome Analysis of Asymptomatic COVID-19 Patients Presenting with Angina- A Retrospective Study |
| title_fullStr | An Outcome Analysis of Asymptomatic COVID-19 Patients Presenting with Angina- A Retrospective Study |
| title_full_unstemmed | An Outcome Analysis of Asymptomatic COVID-19 Patients Presenting with Angina- A Retrospective Study |
| title_short | An Outcome Analysis of Asymptomatic COVID-19 Patients Presenting with Angina- A Retrospective Study |
| title_sort | outcome analysis of asymptomatic covid 19 patients presenting with angina a retrospective study |
| topic | cardiovascular diseases myocardial infarction thrombolysis |
| url | https://jcdr.net/articles/PDF/17577/59103_CE[Ra1]_F(IS)_PF1_(KA_SS)_PFA(KA_KM)_PN(KM).pdf |
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