The Value of <sup>18</sup>F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases: A Systematic Review
(1) Background: Up to 50% of patients with colorectal cancer either have synchronous colorectal liver metastases (CRLM) or develop CRLM over the course of their disease. Surgery and thermal ablation are the most common local treatment options of choice. Despite development and improvement in local t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/3/715 |
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| author | Okker D. Bijlstra Maud M. E. Boreel Sietse van Mossel Mark C. Burgmans Ellen H. W. Kapiteijn Daniela E. Oprea-Lager Daphne D. D. Rietbergen Floris H. P. van Velden Alexander L. Vahrmeijer Rutger-Jan Swijnenburg J. Sven D. Mieog Lioe-Fee de Geus-Oei |
| author_facet | Okker D. Bijlstra Maud M. E. Boreel Sietse van Mossel Mark C. Burgmans Ellen H. W. Kapiteijn Daniela E. Oprea-Lager Daphne D. D. Rietbergen Floris H. P. van Velden Alexander L. Vahrmeijer Rutger-Jan Swijnenburg J. Sven D. Mieog Lioe-Fee de Geus-Oei |
| author_sort | Okker D. Bijlstra |
| collection | DOAJ |
| description | (1) Background: Up to 50% of patients with colorectal cancer either have synchronous colorectal liver metastases (CRLM) or develop CRLM over the course of their disease. Surgery and thermal ablation are the most common local treatment options of choice. Despite development and improvement in local treatment options, (local) recurrence remains a significant clinical problem. Many different imaging modalities can be used in the follow-up after treatment of CRLM, lacking evidence-based international consensus on the modality of choice. In this systematic review, we evaluated <sup>18</sup>F-FDG-PET-CT performance after surgical resection, thermal ablation, radioembolization, and neoadjuvant and palliative chemotherapy based on current published literature. (2) Methods: A systematic literature search was performed on the PubMed database. (3) Results: A total of 31 original articles were included in the analysis. Only one suitable study was found describing the role of <sup>18</sup>F-FDG-PET-CT after surgery, which makes it hard to draw a firm conclusion. <sup>18</sup>F-FDG-PET-CT showed to be of additional value in the follow-up after thermal ablation, palliative chemotherapy, and radioembolization. <sup>18</sup>F-FDG-PET-CT was found to be a poor to moderate predictor of pathologic response after neoadjuvant chemotherapy. (4) Conclusions: <sup>18</sup>F-FDG-PET-CT is superior to conventional morphological imaging modalities in the early detection of residual disease after thermal ablation and in the treatment evaluation and prediction of prognosis during palliative chemotherapy and after radioembolization, and <sup>18</sup>F-FDG-PET-CT could be considered in selected cases after neoadjuvant chemotherapy and surgical resection. |
| first_indexed | 2024-03-09T19:55:53Z |
| format | Article |
| id | doaj.art-5138590af9bd4509b30d021ef5c15f76 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:55:53Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-5138590af9bd4509b30d021ef5c15f762023-11-24T00:56:07ZengMDPI AGDiagnostics2075-44182022-03-0112371510.3390/diagnostics12030715The Value of <sup>18</sup>F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases: A Systematic ReviewOkker D. Bijlstra0Maud M. E. Boreel1Sietse van Mossel2Mark C. Burgmans3Ellen H. W. Kapiteijn4Daniela E. Oprea-Lager5Daphne D. D. Rietbergen6Floris H. P. van Velden7Alexander L. Vahrmeijer8Rutger-Jan Swijnenburg9J. Sven D. Mieog10Lioe-Fee de Geus-Oei11Leiden University Medical Center, Department of Surgery, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsLeiden University Medical Center, Department of Surgery, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Centre, 2333 ZA Leiden, The NetherlandsSection of Interventional Radiology, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Medical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Center, 1081 HV Amsterdam, The NetherlandsSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Centre, 2333 ZA Leiden, The NetherlandsSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Centre, 2333 ZA Leiden, The NetherlandsLeiden University Medical Center, Department of Surgery, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsDepartment of Surgery, Amsterdam University Medical Centers, Cancer Center Amsterdam, University of Amsterdam, 1081 HV Amsterdam, The NetherlandsLeiden University Medical Center, Department of Surgery, Albinusdreef 2, 2333 ZA Leiden, The NetherlandsSection of Nuclear Medicine, Department of Radiology, Leiden University Medical Centre, 2333 ZA Leiden, The Netherlands(1) Background: Up to 50% of patients with colorectal cancer either have synchronous colorectal liver metastases (CRLM) or develop CRLM over the course of their disease. Surgery and thermal ablation are the most common local treatment options of choice. Despite development and improvement in local treatment options, (local) recurrence remains a significant clinical problem. Many different imaging modalities can be used in the follow-up after treatment of CRLM, lacking evidence-based international consensus on the modality of choice. In this systematic review, we evaluated <sup>18</sup>F-FDG-PET-CT performance after surgical resection, thermal ablation, radioembolization, and neoadjuvant and palliative chemotherapy based on current published literature. (2) Methods: A systematic literature search was performed on the PubMed database. (3) Results: A total of 31 original articles were included in the analysis. Only one suitable study was found describing the role of <sup>18</sup>F-FDG-PET-CT after surgery, which makes it hard to draw a firm conclusion. <sup>18</sup>F-FDG-PET-CT showed to be of additional value in the follow-up after thermal ablation, palliative chemotherapy, and radioembolization. <sup>18</sup>F-FDG-PET-CT was found to be a poor to moderate predictor of pathologic response after neoadjuvant chemotherapy. (4) Conclusions: <sup>18</sup>F-FDG-PET-CT is superior to conventional morphological imaging modalities in the early detection of residual disease after thermal ablation and in the treatment evaluation and prediction of prognosis during palliative chemotherapy and after radioembolization, and <sup>18</sup>F-FDG-PET-CT could be considered in selected cases after neoadjuvant chemotherapy and surgical resection.https://www.mdpi.com/2075-4418/12/3/715positron emission tomographycolorectal cancercolorectal liver metastasesfollow-up |
| spellingShingle | Okker D. Bijlstra Maud M. E. Boreel Sietse van Mossel Mark C. Burgmans Ellen H. W. Kapiteijn Daniela E. Oprea-Lager Daphne D. D. Rietbergen Floris H. P. van Velden Alexander L. Vahrmeijer Rutger-Jan Swijnenburg J. Sven D. Mieog Lioe-Fee de Geus-Oei The Value of <sup>18</sup>F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases: A Systematic Review Diagnostics positron emission tomography colorectal cancer colorectal liver metastases follow-up |
| title | The Value of <sup>18</sup>F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases: A Systematic Review |
| title_full | The Value of <sup>18</sup>F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases: A Systematic Review |
| title_fullStr | The Value of <sup>18</sup>F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases: A Systematic Review |
| title_full_unstemmed | The Value of <sup>18</sup>F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases: A Systematic Review |
| title_short | The Value of <sup>18</sup>F-FDG-PET-CT Imaging in Treatment Evaluation of Colorectal Liver Metastases: A Systematic Review |
| title_sort | value of sup 18 sup f fdg pet ct imaging in treatment evaluation of colorectal liver metastases a systematic review |
| topic | positron emission tomography colorectal cancer colorectal liver metastases follow-up |
| url | https://www.mdpi.com/2075-4418/12/3/715 |
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