Theoretical and Experimental Insights into the Tandem Mannich—Electrophilic Amination Reaction: Synthesis of Safirinium Dyes

Theoretical and Experimental Insights into the Tandem Mannich—Electrophilic Amination Reaction: Synthesis of Safirinium Dyes

Isoxazolo[3,4-<i>b</i>]pyridin-3(1<i>H</i>)-ones are ‘spring-loaded’ compounds that quantitatively react with iminium salts derived from formaldehyde and secondary amines to yield fluorescent Safirinium dyes. The mechanism and energetics of the above tandem Mannich–electrophi...

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Bibliographic Details
Main Authors: Jarosław Sączewski, Joanna Fedorowicz, Paulina Wiśniewska, Maria Gdaniec
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Applied Sciences
Subjects:
cationic dyes
DFT
electrophilic amination
isoxazolone
Mannich reaction
spring-loaded reactants
Online Access:https://www.mdpi.com/2076-3417/11/12/5498

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