Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement Study
Background: The aim of this prospective monocentric study was to assess the inter-observer agreement for tumor volume delineations by multiparametric MRI and 18-F-FET-PET/CT in newly diagnosed, untreated high-grade glioma (HGG) patients. Methods: Thirty patients HGG underwent <i>O</i>-(2...
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MDPI AG
2022-08-01
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| Series: | Tomography |
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| Online Access: | https://www.mdpi.com/2379-139X/8/4/170 |
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| author | Brieg Dissaux Doria Mazouz Fatmi Julien Ognard Bastien Allard Nathalie Keromnes Amina Latreche Amandine Lepeuve Ulrike Schick Vincent Bourbonne Douraied Ben Salem Gurvan Dissaux Solène Querellou |
| author_facet | Brieg Dissaux Doria Mazouz Fatmi Julien Ognard Bastien Allard Nathalie Keromnes Amina Latreche Amandine Lepeuve Ulrike Schick Vincent Bourbonne Douraied Ben Salem Gurvan Dissaux Solène Querellou |
| author_sort | Brieg Dissaux |
| collection | DOAJ |
| description | Background: The aim of this prospective monocentric study was to assess the inter-observer agreement for tumor volume delineations by multiparametric MRI and 18-F-FET-PET/CT in newly diagnosed, untreated high-grade glioma (HGG) patients. Methods: Thirty patients HGG underwent <i>O</i>-(2-[18F]-fluoroethyl)-<span style="font-variant: small-caps;">l</span>-tyrosine(18F-FET) positron emission tomography (PET), and multiparametric MRI with computation of rCBV map and K2 map. Three nuclear physicians and three radiologists with different levels of experience delineated the 18-F-FET-PET/CT and 6 MRI sequences, respectively. Spatial similarity (Dice and Jaccard: DSC and JSC) and overlap (Overlap: OV) coefficients were calculated between the readers for each sequence. Results: DSC, JSC, and OV were high for 18F-FET PET/CT, T1-GD, and T2-FLAIR (>0.67). The Spearman correlation coefficient between readers was ≥0.6 for these sequences. Cross-comparison of similarity and overlap parameters showed significant differences for DSC and JSC between 18F-FET PET/CT and T2-FLAIR and for JSC between 18F-FET PET/CT and T1-GD with higher values for 18F-FET PET/CT. No significant difference was found between T1-GD and T2-FLAIR. rCBV, K2, b1000, and ADC showed correlation coefficients between readers <0.6. Conclusion: The interobserver agreements for tumor volume delineations were high for 18-F-FET-PET/CT, T1-GD, and T2-FLAIR. The DWI (b1000, ADC), rCBV, and K2-based sequences, as performed, did not seem sufficiently reproducible to be used in daily practice. |
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| issn | 2379-1381 2379-139X |
| language | English |
| last_indexed | 2024-03-10T01:54:54Z |
| publishDate | 2022-08-01 |
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| spelling | doaj.art-513d2ac2a6994ee0b56738600de97def2023-11-23T12:59:15ZengMDPI AGTomography2379-13812379-139X2022-08-01842030204110.3390/tomography8040170Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement StudyBrieg Dissaux0Doria Mazouz Fatmi1Julien Ognard2Bastien Allard3Nathalie Keromnes4Amina Latreche5Amandine Lepeuve6Ulrike Schick7Vincent Bourbonne8Douraied Ben Salem9Gurvan Dissaux10Solène Querellou11Radiology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, FranceRadiology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, FranceRadiology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, FranceNuclear Medicine Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, FranceNuclear Medicine Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, FranceRadiation Oncology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, FranceUFR Médecine, Université de Bretagne Occidentale, 22, rue Camille Desmoulins-CS93837, CEDEX 3, 29238 Brest, FranceUFR Médecine, Université de Bretagne Occidentale, 22, rue Camille Desmoulins-CS93837, CEDEX 3, 29238 Brest, FranceUFR Médecine, Université de Bretagne Occidentale, 22, rue Camille Desmoulins-CS93837, CEDEX 3, 29238 Brest, FranceRadiology Department, University Hospital, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, FranceUFR Médecine, Université de Bretagne Occidentale, 22, rue Camille Desmoulins-CS93837, CEDEX 3, 29238 Brest, FranceGroupe d’Étude de la Thrombose Occidentale GETBO (Inserm UMR 1304), Université de Bretagne Occidentale, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, CEDEX, 29609 Brest, FranceBackground: The aim of this prospective monocentric study was to assess the inter-observer agreement for tumor volume delineations by multiparametric MRI and 18-F-FET-PET/CT in newly diagnosed, untreated high-grade glioma (HGG) patients. Methods: Thirty patients HGG underwent <i>O</i>-(2-[18F]-fluoroethyl)-<span style="font-variant: small-caps;">l</span>-tyrosine(18F-FET) positron emission tomography (PET), and multiparametric MRI with computation of rCBV map and K2 map. Three nuclear physicians and three radiologists with different levels of experience delineated the 18-F-FET-PET/CT and 6 MRI sequences, respectively. Spatial similarity (Dice and Jaccard: DSC and JSC) and overlap (Overlap: OV) coefficients were calculated between the readers for each sequence. Results: DSC, JSC, and OV were high for 18F-FET PET/CT, T1-GD, and T2-FLAIR (>0.67). The Spearman correlation coefficient between readers was ≥0.6 for these sequences. Cross-comparison of similarity and overlap parameters showed significant differences for DSC and JSC between 18F-FET PET/CT and T2-FLAIR and for JSC between 18F-FET PET/CT and T1-GD with higher values for 18F-FET PET/CT. No significant difference was found between T1-GD and T2-FLAIR. rCBV, K2, b1000, and ADC showed correlation coefficients between readers <0.6. Conclusion: The interobserver agreements for tumor volume delineations were high for 18-F-FET-PET/CT, T1-GD, and T2-FLAIR. The DWI (b1000, ADC), rCBV, and K2-based sequences, as performed, did not seem sufficiently reproducible to be used in daily practice.https://www.mdpi.com/2379-139X/8/4/170inter-observer agreement study18-F-FET-PET/CThigh-grade gliomatumor volume delineationmultiparametric MRI |
| spellingShingle | Brieg Dissaux Doria Mazouz Fatmi Julien Ognard Bastien Allard Nathalie Keromnes Amina Latreche Amandine Lepeuve Ulrike Schick Vincent Bourbonne Douraied Ben Salem Gurvan Dissaux Solène Querellou Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement Study Tomography inter-observer agreement study 18-F-FET-PET/CT high-grade glioma tumor volume delineation multiparametric MRI |
| title | Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement Study |
| title_full | Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement Study |
| title_fullStr | Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement Study |
| title_full_unstemmed | Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement Study |
| title_short | Radiotherapy Target Volume Definition in Newly Diagnosed High-Grade Glioma Using 18F-FET PET Imaging and Multiparametric MRI: An Inter Observer Agreement Study |
| title_sort | radiotherapy target volume definition in newly diagnosed high grade glioma using 18f fet pet imaging and multiparametric mri an inter observer agreement study |
| topic | inter-observer agreement study 18-F-FET-PET/CT high-grade glioma tumor volume delineation multiparametric MRI |
| url | https://www.mdpi.com/2379-139X/8/4/170 |
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