Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions
IntroductionThe aim of this retrospective study was to determine whether there is an association between leukoreduction of packed red blood cell (pRBC) units and reduction of clinically observed transfusion reactions (TR), particularly febrile non-haemolytic transfusion reactions (FNHTR), and better...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1217575/full |
| _version_ | 1797671594023190528 |
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| author | Barbara Steblaj Jasmin Galli Paul Torgerson Annette Kutter |
| author_facet | Barbara Steblaj Jasmin Galli Paul Torgerson Annette Kutter |
| author_sort | Barbara Steblaj |
| collection | DOAJ |
| description | IntroductionThe aim of this retrospective study was to determine whether there is an association between leukoreduction of packed red blood cell (pRBC) units and reduction of clinically observed transfusion reactions (TR), particularly febrile non-haemolytic transfusion reactions (FNHTR), and better outcomes in dogs. Secondary aims were to evaluate the effects of other factors suspected to influence transfusion reaction frequency or survival, including crossmatching, use of immunosuppressive drugs, and age and number of the blood products being administered.Materials and methodsMedical data on dogs transfused with leukocyte-reduced (LR) and non-leukocyte-reduced (N-LR) pRBC units at the Animal Hospital Zürich, University of Zürich, Switzerland between January 1, 2007, and December 17, 2018 were searched. Before 2014, only N-LR blood were transfused. After 2014, both LR and N-LR blood were available.ResultsA total of 339 canine patients were transfused with 413 pRBC units; 30.5% (126/413) were LR units and 69.5% (287/413) were N-LR. Data collected from medical records was analyzed using univariate and multivariate logistic regression. In the present study, TR occurred in 19.8% of pRBC units (25/126) with LR and in 17.7% (51/287) of pRBC with N-LR; p > 0.05. FNHTR occurred in 6.3% of pRBC units (8/126) with LR and in 4.5% (13/287) of those with N-LR; p > 0.05. There was no correlation between the occurrence of TR and discharge from hospital (p > 0.05). Crossmatching, immunosuppressive therapy, and age of the blood product were not associated with the frequency of TR; p > 0.05 for all. The duration of survival days was not related to the number of transfusions dogs received.DiscussionIn the present study, the leukocyte-depletion of transfused pRBC units was not associated with fewer TR nor to fewer FNHTR compared to N-LR units. Discharge of dogs from hospital was not dependent on the occurrence of TR. |
| first_indexed | 2024-03-11T21:17:48Z |
| format | Article |
| id | doaj.art-513d6607b41f4d10ba40a0340a5a7595 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-11T21:17:48Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-513d6607b41f4d10ba40a0340a5a75952023-09-28T14:00:20ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-09-011010.3389/fvets.2023.12175751217575Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactionsBarbara Steblaj0Jasmin Galli1Paul Torgerson2Annette Kutter3Section of Anaesthesiology, Department of Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zürich, Zürich, SwitzerlandInstitute of Veterinary Anatomy, Vetsuisse Faculty, University of Zürich, Zürich, SwitzerlandSection of Epidemiology, Vetsuisse Faculty, University of Zürich, Zürich, SwitzerlandSection of Anaesthesiology, Department of Clinical Diagnostics and Services, Vetsuisse Faculty, University of Zürich, Zürich, SwitzerlandIntroductionThe aim of this retrospective study was to determine whether there is an association between leukoreduction of packed red blood cell (pRBC) units and reduction of clinically observed transfusion reactions (TR), particularly febrile non-haemolytic transfusion reactions (FNHTR), and better outcomes in dogs. Secondary aims were to evaluate the effects of other factors suspected to influence transfusion reaction frequency or survival, including crossmatching, use of immunosuppressive drugs, and age and number of the blood products being administered.Materials and methodsMedical data on dogs transfused with leukocyte-reduced (LR) and non-leukocyte-reduced (N-LR) pRBC units at the Animal Hospital Zürich, University of Zürich, Switzerland between January 1, 2007, and December 17, 2018 were searched. Before 2014, only N-LR blood were transfused. After 2014, both LR and N-LR blood were available.ResultsA total of 339 canine patients were transfused with 413 pRBC units; 30.5% (126/413) were LR units and 69.5% (287/413) were N-LR. Data collected from medical records was analyzed using univariate and multivariate logistic regression. In the present study, TR occurred in 19.8% of pRBC units (25/126) with LR and in 17.7% (51/287) of pRBC with N-LR; p > 0.05. FNHTR occurred in 6.3% of pRBC units (8/126) with LR and in 4.5% (13/287) of those with N-LR; p > 0.05. There was no correlation between the occurrence of TR and discharge from hospital (p > 0.05). Crossmatching, immunosuppressive therapy, and age of the blood product were not associated with the frequency of TR; p > 0.05 for all. The duration of survival days was not related to the number of transfusions dogs received.DiscussionIn the present study, the leukocyte-depletion of transfused pRBC units was not associated with fewer TR nor to fewer FNHTR compared to N-LR units. Discharge of dogs from hospital was not dependent on the occurrence of TR.https://www.frontiersin.org/articles/10.3389/fvets.2023.1217575/fullblood productcanineerythrocytesleukocyte reductionoutcomesurvival |
| spellingShingle | Barbara Steblaj Jasmin Galli Paul Torgerson Annette Kutter Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions Frontiers in Veterinary Science blood product canine erythrocytes leukocyte reduction outcome survival |
| title | Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions |
| title_full | Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions |
| title_fullStr | Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions |
| title_full_unstemmed | Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions |
| title_short | Evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions |
| title_sort | evaluation of leukocyte depletion of packed red blood cell units and impact on clinically observed transfusion reactions |
| topic | blood product canine erythrocytes leukocyte reduction outcome survival |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1217575/full |
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