Advances in the Asymmetric Synthesis of BINOL Derivatives
BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/1/12 |
| _version_ | 1797406705747755008 |
|---|---|
| author | Everton Machado da Silva Hérika Danielle Almeida Vidal Marcelo Augusto Pereira Januário Arlene Gonçalves Corrêa |
| author_facet | Everton Machado da Silva Hérika Danielle Almeida Vidal Marcelo Augusto Pereira Januário Arlene Gonçalves Corrêa |
| author_sort | Everton Machado da Silva |
| collection | DOAJ |
| description | BINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral BINOLs, highlighting the use of metal complexes and organocatalysts as well as kinetic resolution. Further derivatizations of BINOLs are also discussed. |
| first_indexed | 2024-03-09T03:30:26Z |
| format | Article |
| id | doaj.art-5140277daf704cbb8994c7351315fa0f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T03:30:26Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5140277daf704cbb8994c7351315fa0f2023-12-03T14:56:04ZengMDPI AGMolecules1420-30492022-12-012811210.3390/molecules28010012Advances in the Asymmetric Synthesis of BINOL DerivativesEverton Machado da Silva0Hérika Danielle Almeida Vidal1Marcelo Augusto Pereira Januário2Arlene Gonçalves Corrêa3Centre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, BrazilCentre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, BrazilCentre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, BrazilCentre of Excellence for Research on Sustainable Chemistry, Department of Chemistry, Federal University of São Carlos, São Carlos 13565-905, BrazilBINOL derivatives have shown relevant biological activities and are important chiral ligands and catalysts. Due to these properties, their asymmetric synthesis has attracted the interest of the scientific community. In this work, we present an overview of the most efficient methods to obtain chiral BINOLs, highlighting the use of metal complexes and organocatalysts as well as kinetic resolution. Further derivatizations of BINOLs are also discussed.https://www.mdpi.com/1420-3049/28/1/12BINOLchirality transfermetal-mediated enantioselective couplingorganocatalysiskinetic resolution |
| spellingShingle | Everton Machado da Silva Hérika Danielle Almeida Vidal Marcelo Augusto Pereira Januário Arlene Gonçalves Corrêa Advances in the Asymmetric Synthesis of BINOL Derivatives Molecules BINOL chirality transfer metal-mediated enantioselective coupling organocatalysis kinetic resolution |
| title | Advances in the Asymmetric Synthesis of BINOL Derivatives |
| title_full | Advances in the Asymmetric Synthesis of BINOL Derivatives |
| title_fullStr | Advances in the Asymmetric Synthesis of BINOL Derivatives |
| title_full_unstemmed | Advances in the Asymmetric Synthesis of BINOL Derivatives |
| title_short | Advances in the Asymmetric Synthesis of BINOL Derivatives |
| title_sort | advances in the asymmetric synthesis of binol derivatives |
| topic | BINOL chirality transfer metal-mediated enantioselective coupling organocatalysis kinetic resolution |
| url | https://www.mdpi.com/1420-3049/28/1/12 |
| work_keys_str_mv | AT evertonmachadodasilva advancesintheasymmetricsynthesisofbinolderivatives AT herikadaniellealmeidavidal advancesintheasymmetricsynthesisofbinolderivatives AT marceloaugustopereirajanuario advancesintheasymmetricsynthesisofbinolderivatives AT arlenegoncalvescorrea advancesintheasymmetricsynthesisofbinolderivatives |