Etiologies and hearing status in bilateral vestibulopathy: a retrospective study of 315 patients
ImportanceThe development of a vestibular implant has reached milestones and seems to be a promising therapeutic tool for bilateral vestibulopathy (BV). Given the former lack of therapeutic options for BV, the disease has received scant attention in the previous research literature. It is therefore...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1271012/full |
| _version_ | 1797448588531335168 |
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| author | Julie Moyaert Julie Moyaert Bieke Dobbels Bieke Dobbels Olivier Peetermans Bram Boon Florence Lucieer Nils Guinand Griet Mertens Griet Mertens Annick Gilles Annick Gilles Paul van de Heyning Paul van de Heyning Angelica Pérez Fornos Raymond van de Berg Raymond van de Berg Vincent Van Rompaey Vincent Van Rompaey |
| author_facet | Julie Moyaert Julie Moyaert Bieke Dobbels Bieke Dobbels Olivier Peetermans Bram Boon Florence Lucieer Nils Guinand Griet Mertens Griet Mertens Annick Gilles Annick Gilles Paul van de Heyning Paul van de Heyning Angelica Pérez Fornos Raymond van de Berg Raymond van de Berg Vincent Van Rompaey Vincent Van Rompaey |
| author_sort | Julie Moyaert |
| collection | DOAJ |
| description | ImportanceThe development of a vestibular implant has reached milestones and seems to be a promising therapeutic tool for bilateral vestibulopathy (BV). Given the former lack of therapeutic options for BV, the disease has received scant attention in the previous research literature. It is therefore of major importance to gain more insight into the underlying pathology of BV. Furthermore, as some research groups specifically use a combined vestibulo-cochlear implant, the size of the group of BV patients with associated hearing loss is of special interest.ObjectivesThe study aimed to determine the definite and probable etiology in bilateral vestibulopathy (BV) patients and to report on their hearing status.DesignThis study involves multicenter retrospective study design.SettingThe research setting is at tertiary referral centers.ParticipantsConsecutive BV patients diagnosed at the Antwerp University Hospital between 2004 and 2018 at the Maastricht University Medical Center between 2002 and 2015 and at the Geneva University Hospital between 2013 and 2018, who met the BV diagnostic criteria of the Bárány Society.Main outcome measuresPrimary interests were the etiology and hearing status of BV patients. Moreover, the data of vestibular tests were examined (caloric irrigation, rotatory chair tests, and video-head impulse test).ResultsThe authors identified 315 BV patients, of whom 56% were male patients. Mean age at diagnosis was 58.6 ± 15.1 (range 7–91) years. The definite cause was determined in 37% of the patients and the probable cause in 26% of the patients. No cause was identified in 37% of BV patients. The largest subgroup included patients with genetic etiology (31%), most frequently COCH mutation. Only 21% of patients (n = 61) had bilateral normal hearing. Almost half of the patients (45%, n = 134) had profound hearing loss in at least one ear.ConclusionBV is a heterogeneous condition, with over a third of cases remaining idiopathic, and nearly three-quarters affected by hearing loss. COCH mutation is the most common non-idiopathic cause of BV in our population. Only 21% of our BV patients presented with bilateral normal hearing. |
| first_indexed | 2024-03-09T14:12:42Z |
| format | Article |
| id | doaj.art-51416d9bcd354df0acacf9ded2700843 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-09T14:12:42Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-51416d9bcd354df0acacf9ded27008432023-11-29T05:51:31ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-11-011410.3389/fneur.2023.12710121271012Etiologies and hearing status in bilateral vestibulopathy: a retrospective study of 315 patientsJulie Moyaert0Julie Moyaert1Bieke Dobbels2Bieke Dobbels3Olivier Peetermans4Bram Boon5Florence Lucieer6Nils Guinand7Griet Mertens8Griet Mertens9Annick Gilles10Annick Gilles11Paul van de Heyning12Paul van de Heyning13Angelica Pérez Fornos14Raymond van de Berg15Raymond van de Berg16Vincent Van Rompaey17Vincent Van Rompaey18Department of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Health Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, NetherlandsService of Otorhinolaryngology Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, SwitzerlandDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumService of Otorhinolaryngology Head and Neck Surgery, Department of Clinical Neurosciences, Geneva University Hospitals, Geneva, SwitzerlandDivision of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Faculty of Health Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, NetherlandsFaculty of Physics, Tomsk State Research University, Tomsk, RussiaDepartment of Translational Neurosciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, BelgiumDepartment of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, Edegem, BelgiumImportanceThe development of a vestibular implant has reached milestones and seems to be a promising therapeutic tool for bilateral vestibulopathy (BV). Given the former lack of therapeutic options for BV, the disease has received scant attention in the previous research literature. It is therefore of major importance to gain more insight into the underlying pathology of BV. Furthermore, as some research groups specifically use a combined vestibulo-cochlear implant, the size of the group of BV patients with associated hearing loss is of special interest.ObjectivesThe study aimed to determine the definite and probable etiology in bilateral vestibulopathy (BV) patients and to report on their hearing status.DesignThis study involves multicenter retrospective study design.SettingThe research setting is at tertiary referral centers.ParticipantsConsecutive BV patients diagnosed at the Antwerp University Hospital between 2004 and 2018 at the Maastricht University Medical Center between 2002 and 2015 and at the Geneva University Hospital between 2013 and 2018, who met the BV diagnostic criteria of the Bárány Society.Main outcome measuresPrimary interests were the etiology and hearing status of BV patients. Moreover, the data of vestibular tests were examined (caloric irrigation, rotatory chair tests, and video-head impulse test).ResultsThe authors identified 315 BV patients, of whom 56% were male patients. Mean age at diagnosis was 58.6 ± 15.1 (range 7–91) years. The definite cause was determined in 37% of the patients and the probable cause in 26% of the patients. No cause was identified in 37% of BV patients. The largest subgroup included patients with genetic etiology (31%), most frequently COCH mutation. Only 21% of patients (n = 61) had bilateral normal hearing. Almost half of the patients (45%, n = 134) had profound hearing loss in at least one ear.ConclusionBV is a heterogeneous condition, with over a third of cases remaining idiopathic, and nearly three-quarters affected by hearing loss. COCH mutation is the most common non-idiopathic cause of BV in our population. Only 21% of our BV patients presented with bilateral normal hearing.https://www.frontiersin.org/articles/10.3389/fneur.2023.1271012/fullbilateral vestibulopathyhearing lossCOCH proteinhumancausalityMeniere disease |
| spellingShingle | Julie Moyaert Julie Moyaert Bieke Dobbels Bieke Dobbels Olivier Peetermans Bram Boon Florence Lucieer Nils Guinand Griet Mertens Griet Mertens Annick Gilles Annick Gilles Paul van de Heyning Paul van de Heyning Angelica Pérez Fornos Raymond van de Berg Raymond van de Berg Vincent Van Rompaey Vincent Van Rompaey Etiologies and hearing status in bilateral vestibulopathy: a retrospective study of 315 patients Frontiers in Neurology bilateral vestibulopathy hearing loss COCH protein human causality Meniere disease |
| title | Etiologies and hearing status in bilateral vestibulopathy: a retrospective study of 315 patients |
| title_full | Etiologies and hearing status in bilateral vestibulopathy: a retrospective study of 315 patients |
| title_fullStr | Etiologies and hearing status in bilateral vestibulopathy: a retrospective study of 315 patients |
| title_full_unstemmed | Etiologies and hearing status in bilateral vestibulopathy: a retrospective study of 315 patients |
| title_short | Etiologies and hearing status in bilateral vestibulopathy: a retrospective study of 315 patients |
| title_sort | etiologies and hearing status in bilateral vestibulopathy a retrospective study of 315 patients |
| topic | bilateral vestibulopathy hearing loss COCH protein human causality Meniere disease |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1271012/full |
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