| Summary: | Medical diagnosis research has recently focused on feature selection techniques due to the availability of multiple variables in medical datasets. Wrapper-based feature selection approaches have shown promise in providing faster and more cost-effective predictors. However, selecting the most relevant features from medical datasets to increase disease classification accuracy remains a challenging research issue. To address this challenge, we propose an effective wrapper-based feature selection approach called BTLBO-KNN. It combines an improved Binary Teaching-Learning Based Optimization (BTLBO) algorithm with the K-Nearest Neighbor (KNN) classifier to accelerate the convergence rate in finding the near-optimal features subset. BTLBO-KNN incorporates two new efficient binary teaching and learning processes, an abandoned learner’s replacement mechanism, and a teacher knowledge improvement method. We extensively compare BTLBO-KNN with recent state-of-the-art wrapper-based feature selection approaches on COVID-19 and 23 gene-expression and medical datasets with different dimensional complexities. Our results demonstrate the superiority of BTLBO-KNN over its alternatives in terms of minimizing the number of selected features and the classification error rate.
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