Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.

Immunotherapy using regulatory T cells (Treg) has been proposed, yet cellular and molecular mechanisms of human Tregs remain incompletely characterized. Here, we demonstrate that human Tregs promote the generation of myeloid dendritic cells (DC) with reduced capacity to stimulate effector T cell res...

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Bibliographic Details
Main Authors: Shoba Amarnath, Carliann M Costanzo, Jacopo Mariotti, Jessica L Ullman, William G Telford, Veena Kapoor, James L Riley, Bruce L Levine, Carl H June, Timothy Fong, Noel L Warner, Daniel H Fowler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2814822?pdf=render

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