A case–control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic stroke

Background: Ischemic stroke is known to be one of the foremost causes of long-term disability and death, and platelets play a pivotal role in its pathophysiology. However, the platelet indices having a role in ischemic stroke are not routinely reported in the available literature. Objective: The obj...

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Main Authors: Meenatchi Sundari, Mohamed Hanifah, Dhananjay S Kotasthane, K Jayasingh
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2021-01-01
Series:Sahel Medical Journal
Subjects:
Online Access:http://www.smjonline.org/article.asp?issn=1118-8561;year=2021;volume=24;issue=1;spage=10;epage=14;aulast=Sundari
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author Meenatchi Sundari
Mohamed Hanifah
Dhananjay S Kotasthane
K Jayasingh
author_facet Meenatchi Sundari
Mohamed Hanifah
Dhananjay S Kotasthane
K Jayasingh
author_sort Meenatchi Sundari
collection DOAJ
description Background: Ischemic stroke is known to be one of the foremost causes of long-term disability and death, and platelets play a pivotal role in its pathophysiology. However, the platelet indices having a role in ischemic stroke are not routinely reported in the available literature. Objective: The objective of the study was to evaluate the potential role of mean platelet volume (MPV) and platelet distribution width (PDW) in the development of ischemic stroke, especially in the South Indian region. Materials and Methods: This case–control study was conducted on 80 patients who were broadly divided into two groups: the case group (patients with ischemic stroke) and the control group (patients without ischemic stroke). Platelet indices were measured using Mindray BC-5200 auto hematology analyzer, and the results were analyzed using Student's t-test and Wilcoxon rank-sum Test. Results: There was a statistically significant difference (P < 0.001) in the MPV and PDW values between the two groups. The difference between the area under the curve for both MPV and PDW was also found to be statistically significant (P < 0.001) in the receiver operating characteristic curve. However, the differences in the values of MPV and PDW across different age groups, genders, and various comorbid conditions were not found to be significant. Conclusion: The elevated platelet indices may be associated with the development of ischemic stroke. The MPV and PDW can be prospective biochemical markers for predicting the onset of ischemic stroke.
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spelling doaj.art-51455475333f4c70a0ff0fb27c0e5cb52022-12-21T19:06:38ZengWolters Kluwer Medknow PublicationsSahel Medical Journal2321-66892021-01-01241101410.4103/smj.smj_19_20A case–control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic strokeMeenatchi SundariMohamed HanifahDhananjay S KotasthaneK JayasinghBackground: Ischemic stroke is known to be one of the foremost causes of long-term disability and death, and platelets play a pivotal role in its pathophysiology. However, the platelet indices having a role in ischemic stroke are not routinely reported in the available literature. Objective: The objective of the study was to evaluate the potential role of mean platelet volume (MPV) and platelet distribution width (PDW) in the development of ischemic stroke, especially in the South Indian region. Materials and Methods: This case–control study was conducted on 80 patients who were broadly divided into two groups: the case group (patients with ischemic stroke) and the control group (patients without ischemic stroke). Platelet indices were measured using Mindray BC-5200 auto hematology analyzer, and the results were analyzed using Student's t-test and Wilcoxon rank-sum Test. Results: There was a statistically significant difference (P < 0.001) in the MPV and PDW values between the two groups. The difference between the area under the curve for both MPV and PDW was also found to be statistically significant (P < 0.001) in the receiver operating characteristic curve. However, the differences in the values of MPV and PDW across different age groups, genders, and various comorbid conditions were not found to be significant. Conclusion: The elevated platelet indices may be associated with the development of ischemic stroke. The MPV and PDW can be prospective biochemical markers for predicting the onset of ischemic stroke.http://www.smjonline.org/article.asp?issn=1118-8561;year=2021;volume=24;issue=1;spage=10;epage=14;aulast=Sundariblood plateletsbrain ischemiahematologymean platelet volumereceiver operating characteristic curve
spellingShingle Meenatchi Sundari
Mohamed Hanifah
Dhananjay S Kotasthane
K Jayasingh
A case–control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic stroke
Sahel Medical Journal
blood platelets
brain ischemia
hematology
mean platelet volume
receiver operating characteristic curve
title A case–control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic stroke
title_full A case–control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic stroke
title_fullStr A case–control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic stroke
title_full_unstemmed A case–control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic stroke
title_short A case–control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic stroke
title_sort case control study to evaluate the role of mean platelet volume and platelet distribution width in acute ischemic stroke
topic blood platelets
brain ischemia
hematology
mean platelet volume
receiver operating characteristic curve
url http://www.smjonline.org/article.asp?issn=1118-8561;year=2021;volume=24;issue=1;spage=10;epage=14;aulast=Sundari
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