Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF
Objectives: To determine the live birth rate for patients who chose to undergo treatment with Restorative Reproductive Medicine (RRM) after previous IVF (includes ICSI). To look at birth outcomes with RRM after IVF, particularly rates of twin and higher order pregnancies, premature birth, low birth...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-07-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2018.00210/full |
| _version_ | 1818200850084921344 |
|---|---|
| author | Phil C. Boyle Phil C. Boyle Theun de Groot Karolina M. Andralojc Tracey A. Parnell Tracey A. Parnell |
| author_facet | Phil C. Boyle Phil C. Boyle Theun de Groot Karolina M. Andralojc Tracey A. Parnell Tracey A. Parnell |
| author_sort | Phil C. Boyle |
| collection | DOAJ |
| description | Objectives: To determine the live birth rate for patients who chose to undergo treatment with Restorative Reproductive Medicine (RRM) after previous IVF (includes ICSI). To look at birth outcomes with RRM after IVF, particularly rates of twin and higher order pregnancies, premature birth, low birth weight, and potential cost savings achieved with RRM.Setting: Two outpatient clinics in Ireland providing advanced RRM treatment of infertility.Materials and methods: All patients presenting between January 2004 and January 2010, with a history of infertility and previous IVF treatment were included if they proceeded beyond the initial consultation and began treatment. Main outcome is live birth per couple calculated using life table analysis.Results: 403 patients met the study criteria, among which 74 had a subsequent live birth. These women had significant negative predictive characteristics for healthy live birth including: advanced reproductive age (average 37.2 years), an average of 5.8 years of infertility with 2.1 (range 1–9) previous IVF attempts, with only 5% having previously had a live birth from IVF. Despite these undesirable prognostic indicators, the overall RRM live birth rate was 32.1% (crude 18.4%). Women aged 35–38 had a live birth rate of 37.5% (crude 23.6%) and older women over 40 had a live birth rate of 27.4% (crude 16.0%). The average birth weight was 3374g (7lb 7oz) with 92% being born at 37+ weeks and no very low birth weight babies. There was only one twin pregnancy in the study population; the potential health care savings for avoidable multiple pregnancies in these patients was estimated at £205 672 (USD$284 915).Conclusions: Patients who have already tried IVF can achieve comparable live birth outcomes with RRM compared to another cycle of IVF. RRM has a low risk of twin or multiple births, and very good neonatal outcomes with a potential cost savings to the health care system. |
| first_indexed | 2024-12-12T02:44:12Z |
| format | Article |
| id | doaj.art-5146402a9b6b4439b663f2f27b9e1398 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-12T02:44:12Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-5146402a9b6b4439b663f2f27b9e13982022-12-22T00:41:05ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2018-07-01510.3389/fmed.2018.00210371473Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVFPhil C. Boyle0Phil C. Boyle1Theun de Groot2Karolina M. Andralojc3Tracey A. Parnell4Tracey A. Parnell5International Institute for Restorative Reproductive Medicine, London, United KingdomNeoFertility Clinic, Dublin, IrelandInternational Institute for Restorative Reproductive Medicine, London, United KingdomDepartment of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, NetherlandsInternational Institute for Restorative Reproductive Medicine, London, United KingdomDepartment of Family Medicine, University of British Columbia, Vancouver, BC, CanadaObjectives: To determine the live birth rate for patients who chose to undergo treatment with Restorative Reproductive Medicine (RRM) after previous IVF (includes ICSI). To look at birth outcomes with RRM after IVF, particularly rates of twin and higher order pregnancies, premature birth, low birth weight, and potential cost savings achieved with RRM.Setting: Two outpatient clinics in Ireland providing advanced RRM treatment of infertility.Materials and methods: All patients presenting between January 2004 and January 2010, with a history of infertility and previous IVF treatment were included if they proceeded beyond the initial consultation and began treatment. Main outcome is live birth per couple calculated using life table analysis.Results: 403 patients met the study criteria, among which 74 had a subsequent live birth. These women had significant negative predictive characteristics for healthy live birth including: advanced reproductive age (average 37.2 years), an average of 5.8 years of infertility with 2.1 (range 1–9) previous IVF attempts, with only 5% having previously had a live birth from IVF. Despite these undesirable prognostic indicators, the overall RRM live birth rate was 32.1% (crude 18.4%). Women aged 35–38 had a live birth rate of 37.5% (crude 23.6%) and older women over 40 had a live birth rate of 27.4% (crude 16.0%). The average birth weight was 3374g (7lb 7oz) with 92% being born at 37+ weeks and no very low birth weight babies. There was only one twin pregnancy in the study population; the potential health care savings for avoidable multiple pregnancies in these patients was estimated at £205 672 (USD$284 915).Conclusions: Patients who have already tried IVF can achieve comparable live birth outcomes with RRM compared to another cycle of IVF. RRM has a low risk of twin or multiple births, and very good neonatal outcomes with a potential cost savings to the health care system.https://www.frontiersin.org/article/10.3389/fmed.2018.00210/fullinfertilityrestorative reproductive medicineRRMIVF failurefertility treatmentprevention premature birth |
| spellingShingle | Phil C. Boyle Phil C. Boyle Theun de Groot Karolina M. Andralojc Tracey A. Parnell Tracey A. Parnell Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF Frontiers in Medicine infertility restorative reproductive medicine RRM IVF failure fertility treatment prevention premature birth |
| title | Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF |
| title_full | Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF |
| title_fullStr | Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF |
| title_full_unstemmed | Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF |
| title_short | Healthy Singleton Pregnancies From Restorative Reproductive Medicine (RRM) After Failed IVF |
| title_sort | healthy singleton pregnancies from restorative reproductive medicine rrm after failed ivf |
| topic | infertility restorative reproductive medicine RRM IVF failure fertility treatment prevention premature birth |
| url | https://www.frontiersin.org/article/10.3389/fmed.2018.00210/full |
| work_keys_str_mv | AT philcboyle healthysingletonpregnanciesfromrestorativereproductivemedicinerrmafterfailedivf AT philcboyle healthysingletonpregnanciesfromrestorativereproductivemedicinerrmafterfailedivf AT theundegroot healthysingletonpregnanciesfromrestorativereproductivemedicinerrmafterfailedivf AT karolinamandralojc healthysingletonpregnanciesfromrestorativereproductivemedicinerrmafterfailedivf AT traceyaparnell healthysingletonpregnanciesfromrestorativereproductivemedicinerrmafterfailedivf AT traceyaparnell healthysingletonpregnanciesfromrestorativereproductivemedicinerrmafterfailedivf |