Pitavastatin activates mitophagy to protect EPC proliferation through a calcium-dependent CAMK1-PINK1 pathway in atherosclerotic mice

Pitavastatin activates mitophagy to protect EPC proliferation through a calcium-dependent CAMK1-PINK1 pathway in atherosclerotic mice

Endothelial progenitor cell (EPCs) proliferation decreased, accompanied by mitochondrial dysfunction and mitophagy impairment via the PINK1-PARK2 pathway in atherosclerosis. Statins induce mitophagy to protect EPCs by mitochondrial calcium release and CAMK1-mediated PINK1 phosphorylation.

Bibliographic Details
Main Authors: Jie Yang, Mengjia Sun, Ran Cheng, Hu Tan, Chuan Liu, Renzheng Chen, Jihang Zhang, Yuanqi Yang, Xubin Gao, Lan Huang
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-03081-w

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