Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy

Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy

Abstract Background Mitochondrial dysfunction contributes to the pathogenesis of diabetic nephropathy (DN). Mitochondrial pyruvate carrier 1 (MPC1) and mitochondrial pyruvate carrier 2 (MPC2) play a bottleneck role in the transport of pyruvate into mitochondrial across the mitochondrial inner membra...

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Bibliographic Details
Main Authors: Huanhuan Zhu, Huiting Wan, Lin Wu, Qing Li, Simeng Liu, Suyan Duan, Zhimin Huang, Chengning Zhang, Bo Zhang, Changying Xing, Yanggang Yuan
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Nephrology
Subjects:
Mitochondrial pyruvate carrier
Mitochondria
Diabetic nephropathy
Online Access:http://link.springer.com/article/10.1186/s12882-020-01931-5

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