Structural Investigation for Optimization of Anthranilic Acid Derivatives as Partial FXR Agonists by in Silico Approaches

Structural Investigation for Optimization of Anthranilic Acid Derivatives as Partial FXR Agonists by in Silico Approaches

In this paper, a three level in silico approach was applied to investigate some important structural and physicochemical aspects of a series of anthranilic acid derivatives (AAD) newly identified as potent partial farnesoid X receptor (FXR) agonists. Initially, both two and three-dimensional quantit...

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Bibliographic Details
Main Authors: Meimei Chen, Xuemei Yang, Xinmei Lai, Jie Kang, Huijuan Gan, Yuxing Gao
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:International Journal of Molecular Sciences
Subjects:
QSAR
docking
FXR
anthranilic acid derivatives
Online Access:http://www.mdpi.com/1422-0067/17/4/536

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