Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy
Abstract Litchi chinensis seed, as a valuable by-product of the subtropical fruit litchi (Litchi chinensis Sonn.), has been confirmed to be rich in procyanidins (LPC). The anticarcinogenic properties of procyanidins has been primarily attributed to their antioxidant and anti-inflammatory activities....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2023-02-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-022-05482-5 |
| _version_ | 1811165697457258496 |
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| author | Yuan Yao Suya Feng Xuejiao Li Taohua Liu Shengying Ye Long Ma Shuli Man |
| author_facet | Yuan Yao Suya Feng Xuejiao Li Taohua Liu Shengying Ye Long Ma Shuli Man |
| author_sort | Yuan Yao |
| collection | DOAJ |
| description | Abstract Litchi chinensis seed, as a valuable by-product of the subtropical fruit litchi (Litchi chinensis Sonn.), has been confirmed to be rich in procyanidins (LPC). The anticarcinogenic properties of procyanidins has been primarily attributed to their antioxidant and anti-inflammatory activities. However, there is a comparative paucity of information on if and how LPC inhibits colon cancer. Here, LPC significantly inhibited CT26 colon cancer cells proliferation and metastasis in vivo and in vitro. In CT26 lung metastatic mice, the anti-metastatic effect of LPC relied on its regulation of gut microbiota such as increase of Lachnospiraceae UCG-006, Ruminococcus, and their metabolites such as acetic acid, propionic acid and butyric acid. In addition, LPC significantly inhibited CT26 colon cancer cells metastasis through increasing CD8+ cytotoxic T lymphocytes infiltration and decreasing the number of macrophages. Antibiotics treatment demonstrated that the therapeutic effect of LPC depended on the gut microbiota, which regulated T cells immune response. Taken together, LPC had strong inhibitory effects on colon cancer pulmonary metastasis by triggering gut-lung axis to influence the T cells immune response. Our research provides a novel finding for the utilization of procyanidins in the future, that is, supplementing more fruits and vegetables rich in procyanidins is beneficial to the treatment of colon cancer, or it can be used as an adjuvant drug in clinical anti-tumor immunotherapy. |
| first_indexed | 2024-04-10T15:40:51Z |
| format | Article |
| id | doaj.art-5148f077b19b43cd94dff7e6194c38d7 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-04-10T15:40:51Z |
| publishDate | 2023-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-5148f077b19b43cd94dff7e6194c38d72023-02-12T12:24:15ZengNature Publishing GroupCell Death and Disease2041-48892023-02-0114211110.1038/s41419-022-05482-5Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapyYuan Yao0Suya Feng1Xuejiao Li2Taohua Liu3Shengying Ye4Long Ma5Shuli Man6State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & TechnologyState Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & TechnologyHenan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and TechnologyState Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & TechnologyDepartment of Pharmacy, The 983th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation ArmyState Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & TechnologyState Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, National and Local United Engineering Lab of Metabolic Control Fermentation Technology, China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology, Tianjin University of Science & TechnologyAbstract Litchi chinensis seed, as a valuable by-product of the subtropical fruit litchi (Litchi chinensis Sonn.), has been confirmed to be rich in procyanidins (LPC). The anticarcinogenic properties of procyanidins has been primarily attributed to their antioxidant and anti-inflammatory activities. However, there is a comparative paucity of information on if and how LPC inhibits colon cancer. Here, LPC significantly inhibited CT26 colon cancer cells proliferation and metastasis in vivo and in vitro. In CT26 lung metastatic mice, the anti-metastatic effect of LPC relied on its regulation of gut microbiota such as increase of Lachnospiraceae UCG-006, Ruminococcus, and their metabolites such as acetic acid, propionic acid and butyric acid. In addition, LPC significantly inhibited CT26 colon cancer cells metastasis through increasing CD8+ cytotoxic T lymphocytes infiltration and decreasing the number of macrophages. Antibiotics treatment demonstrated that the therapeutic effect of LPC depended on the gut microbiota, which regulated T cells immune response. Taken together, LPC had strong inhibitory effects on colon cancer pulmonary metastasis by triggering gut-lung axis to influence the T cells immune response. Our research provides a novel finding for the utilization of procyanidins in the future, that is, supplementing more fruits and vegetables rich in procyanidins is beneficial to the treatment of colon cancer, or it can be used as an adjuvant drug in clinical anti-tumor immunotherapy.https://doi.org/10.1038/s41419-022-05482-5 |
| spellingShingle | Yuan Yao Suya Feng Xuejiao Li Taohua Liu Shengying Ye Long Ma Shuli Man Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy Cell Death and Disease |
| title | Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy |
| title_full | Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy |
| title_fullStr | Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy |
| title_full_unstemmed | Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy |
| title_short | Litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut-lung axis immunotherapy |
| title_sort | litchi procyanidins inhibit colon cancer proliferation and metastasis by triggering gut lung axis immunotherapy |
| url | https://doi.org/10.1038/s41419-022-05482-5 |
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