Human wild‐type and D76N β2‐microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans

Human wild‐type and D76N β2‐microglobulin variants are significant proteotoxic and metabolic stressors for transgenic C. elegans

Abstract β2‐microglobulin (β2‐m) is a plasma protein derived from physiological shedding of the class I major histocompatibility complex (MHCI), causing human systemic amyloidosis either due to persistently high concentrations of the wild‐type (WT) protein in hemodialyzed patients, or in presence of...

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Main Authors: Sara Raimondi, Giulia Faravelli, Paola Nocerino, Valentina Mondani, Alma Baruffaldi, Loredana Marchese, Maria Chiara Mimmi, Diana Canetti, Guglielmo Verona, Marianna Caterino, Margherita Ruoppolo, P. Patrizia Mangione, Vittorio Bellotti, Francesca Lavatelli, Sofia Giorgetti
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:FASEB BioAdvances
Subjects:
C. elegans
integrated omics
misfolding
proteotoxicity
systemic amyloidosis
β2‐microglobulin
Online Access:https://doi.org/10.1096/fba.2023-00073

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