Pathology identifies glomerular treatment targets in diabetic nephropathy
The development of the glomerular injury in diabetic nephropathy involves interactions between podocytes, endothelium, and the mesangium. Loss of podocytes is an early and critical step in the development of diabetic nephropathy, and analysis of structural lesions within the mesangium such as mesang...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2018-06-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.23876/j.krcp.2018.37.2.106 |
| _version_ | 1818343473510612992 |
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| author | Charles E. Alpers Kelly L. Hudkins |
| author_facet | Charles E. Alpers Kelly L. Hudkins |
| author_sort | Charles E. Alpers |
| collection | DOAJ |
| description | The development of the glomerular injury in diabetic nephropathy involves interactions between podocytes, endothelium, and the mesangium. Loss of podocytes is an early and critical step in the development of diabetic nephropathy, and analysis of structural lesions within the mesangium such as mesangiolysis implicate the loss of podocytes as a key mediating event. The BTBR ob/ob mouse has proved a useful tool to demonstrate that restoration of podocyte density, once thought to be an absolute barrier to glomerular repair, can be achieved with replacement of the hormone leptin that is constitutively absent in these mice. Restoration of podocyte density is associated with reversal of the structural lesions of morphologically advanced diabetic glomerular injury in this model. This finding, in conjunction with the demonstration in human diabetic patients with morphologically advanced diabetic nephropathy and with long-standing functioning pancreatic transplants of ten years duration that their diabetic nephropathy can be reversed, suggests that restoration of podocyte number and density is an appropriate target for the development of new therapeutics for diabetic nephropathy. |
| first_indexed | 2024-12-13T16:31:09Z |
| format | Article |
| id | doaj.art-514b99f8ad1945bfbe936a67bfc6edf1 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-13T16:31:09Z |
| publishDate | 2018-06-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-514b99f8ad1945bfbe936a67bfc6edf12022-12-21T23:38:30ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322018-06-0137210611110.23876/j.krcp.2018.37.2.106j.krcp.2018.37.2.106Pathology identifies glomerular treatment targets in diabetic nephropathyCharles E. Alpers0Kelly L. Hudkins1Department of Pathology, University of Washington, Seattle, WA, USADepartment of Pathology, University of Washington, Seattle, WA, USAThe development of the glomerular injury in diabetic nephropathy involves interactions between podocytes, endothelium, and the mesangium. Loss of podocytes is an early and critical step in the development of diabetic nephropathy, and analysis of structural lesions within the mesangium such as mesangiolysis implicate the loss of podocytes as a key mediating event. The BTBR ob/ob mouse has proved a useful tool to demonstrate that restoration of podocyte density, once thought to be an absolute barrier to glomerular repair, can be achieved with replacement of the hormone leptin that is constitutively absent in these mice. Restoration of podocyte density is associated with reversal of the structural lesions of morphologically advanced diabetic glomerular injury in this model. This finding, in conjunction with the demonstration in human diabetic patients with morphologically advanced diabetic nephropathy and with long-standing functioning pancreatic transplants of ten years duration that their diabetic nephropathy can be reversed, suggests that restoration of podocyte number and density is an appropriate target for the development of new therapeutics for diabetic nephropathy.https://doi.org/10.23876/j.krcp.2018.37.2.106Diabetic nephropathiesHistologyPathologyPodocytes |
| spellingShingle | Charles E. Alpers Kelly L. Hudkins Pathology identifies glomerular treatment targets in diabetic nephropathy Kidney Research and Clinical Practice Diabetic nephropathies Histology Pathology Podocytes |
| title | Pathology identifies glomerular treatment targets in diabetic nephropathy |
| title_full | Pathology identifies glomerular treatment targets in diabetic nephropathy |
| title_fullStr | Pathology identifies glomerular treatment targets in diabetic nephropathy |
| title_full_unstemmed | Pathology identifies glomerular treatment targets in diabetic nephropathy |
| title_short | Pathology identifies glomerular treatment targets in diabetic nephropathy |
| title_sort | pathology identifies glomerular treatment targets in diabetic nephropathy |
| topic | Diabetic nephropathies Histology Pathology Podocytes |
| url | https://doi.org/10.23876/j.krcp.2018.37.2.106 |
| work_keys_str_mv | AT charlesealpers pathologyidentifiesglomerulartreatmenttargetsindiabeticnephropathy AT kellylhudkins pathologyidentifiesglomerulartreatmenttargetsindiabeticnephropathy |