Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis.
<h4>Background</h4>To comprehensively investigate risk factors for proliferative vitreoretinopathy (PVR) after retinal detachment (RD) surgery.<h4>Methods</h4>PubMed, Embase, Cochrane Library, and Web of Science were systematically searched until May 22, 2023. Risk factors in...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0292698 |
| _version_ | 1797637516234326016 |
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| author | Jinjin Xiang Jingjing Fan Jiahui Wang |
| author_facet | Jinjin Xiang Jingjing Fan Jiahui Wang |
| author_sort | Jinjin Xiang |
| collection | DOAJ |
| description | <h4>Background</h4>To comprehensively investigate risk factors for proliferative vitreoretinopathy (PVR) after retinal detachment (RD) surgery.<h4>Methods</h4>PubMed, Embase, Cochrane Library, and Web of Science were systematically searched until May 22, 2023. Risk factors included demographic and disease-related risk factors. Odds ratios (ORs) and weighted mean differences (WMDs) were used as the effect sizes, and shown with 95% confidence intervals (CIs). Sensitivity analysis was conducted. The protocol was registered with PROSPERO (CRD42022378652).<h4>Results</h4>Twenty-two studies of 13,875 subjects were included in this systematic review and meta-analysis. Increased age was associated with a higher risk of postoperative PVR (pooled WMD = 3.98, 95%CI: 0.21, 7.75, P = 0.038). Smokers had a higher risk of postoperative PVR than non-smokers (pooled OR = 5.07, 95%CI: 2.21-11.61, P<0.001). Presence of preoperative PVR was associated with a greater risk of postoperative PVR (pooled OR = 22.28, 95%CI: 2.54, 195.31, P = 0.005). Presence of vitreous hemorrhage was associated with a greater risk of postoperative PVR (pooled OR = 4.12, 95%CI: 1.62, 10.50, P = 0.003). Individuals with aphakia or pseudophakia had an increased risk of postoperative PVR in contrast to those without (pooled OR = 1.41, 95%CI: 1.02, 1.95, P = 0.040). The risk of postoperative PVR was higher among patients with macula off versus those with macula on (pooled OR = 1.85, 95%CI: 1.24, 2.74, P = 0.002). Extent of RD in patients with postoperative PVR was larger than that in patients without (pooled WMD = 0.31, 95%CI: 0.02, 0.59, P = 0.036). Patients with postoperative PVR had longer duration of RD symptoms than those without (pooled WMD = 10.36, 95%CI: 2.29, 18.43, P = 0.012).<h4>Conclusion</h4>Age, smoking, preoperative PVR, vitreous hemorrhage, aphakia or pseudophakia, macula off, extent of RD, and duration of RD symptoms were risk factors for postoperative PVR in patients undergoing RD surgery, which may help better identify high-risk patients, and provide timely interventions. |
| first_indexed | 2024-03-11T12:50:33Z |
| format | Article |
| id | doaj.art-514bbb6232444c14a5cafe0d62892789 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-11T12:50:33Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-514bbb6232444c14a5cafe0d628927892023-11-04T05:32:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-011810e029269810.1371/journal.pone.0292698Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis.Jinjin XiangJingjing FanJiahui Wang<h4>Background</h4>To comprehensively investigate risk factors for proliferative vitreoretinopathy (PVR) after retinal detachment (RD) surgery.<h4>Methods</h4>PubMed, Embase, Cochrane Library, and Web of Science were systematically searched until May 22, 2023. Risk factors included demographic and disease-related risk factors. Odds ratios (ORs) and weighted mean differences (WMDs) were used as the effect sizes, and shown with 95% confidence intervals (CIs). Sensitivity analysis was conducted. The protocol was registered with PROSPERO (CRD42022378652).<h4>Results</h4>Twenty-two studies of 13,875 subjects were included in this systematic review and meta-analysis. Increased age was associated with a higher risk of postoperative PVR (pooled WMD = 3.98, 95%CI: 0.21, 7.75, P = 0.038). Smokers had a higher risk of postoperative PVR than non-smokers (pooled OR = 5.07, 95%CI: 2.21-11.61, P<0.001). Presence of preoperative PVR was associated with a greater risk of postoperative PVR (pooled OR = 22.28, 95%CI: 2.54, 195.31, P = 0.005). Presence of vitreous hemorrhage was associated with a greater risk of postoperative PVR (pooled OR = 4.12, 95%CI: 1.62, 10.50, P = 0.003). Individuals with aphakia or pseudophakia had an increased risk of postoperative PVR in contrast to those without (pooled OR = 1.41, 95%CI: 1.02, 1.95, P = 0.040). The risk of postoperative PVR was higher among patients with macula off versus those with macula on (pooled OR = 1.85, 95%CI: 1.24, 2.74, P = 0.002). Extent of RD in patients with postoperative PVR was larger than that in patients without (pooled WMD = 0.31, 95%CI: 0.02, 0.59, P = 0.036). Patients with postoperative PVR had longer duration of RD symptoms than those without (pooled WMD = 10.36, 95%CI: 2.29, 18.43, P = 0.012).<h4>Conclusion</h4>Age, smoking, preoperative PVR, vitreous hemorrhage, aphakia or pseudophakia, macula off, extent of RD, and duration of RD symptoms were risk factors for postoperative PVR in patients undergoing RD surgery, which may help better identify high-risk patients, and provide timely interventions.https://doi.org/10.1371/journal.pone.0292698 |
| spellingShingle | Jinjin Xiang Jingjing Fan Jiahui Wang Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis. PLoS ONE |
| title | Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis. |
| title_full | Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis. |
| title_fullStr | Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis. |
| title_full_unstemmed | Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis. |
| title_short | Risk factors for proliferative vitreoretinopathy after retinal detachment surgery: A systematic review and meta-analysis. |
| title_sort | risk factors for proliferative vitreoretinopathy after retinal detachment surgery a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0292698 |
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