Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis
Abstract Periodontitis, one of the most prevalent dental diseases, causes the loss of bone and gum tissue that hold teeth in place. Several bacteria, commonly present in clinically healthy oral cavities, may induce and perpetuate periodontitis when their concentration rises in the gingival sulcus. A...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-023-02284-5 |
| _version_ | 1827388191036932096 |
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| author | Mohammad Kiarashi Parham Mahamed Nader Ghotbi Azadeh Tadayonfard Kamyar Nasiri Parisa Kazemi Ashkan Badkoobeh Saman Yasamineh Ali Joudaki |
| author_facet | Mohammad Kiarashi Parham Mahamed Nader Ghotbi Azadeh Tadayonfard Kamyar Nasiri Parisa Kazemi Ashkan Badkoobeh Saman Yasamineh Ali Joudaki |
| author_sort | Mohammad Kiarashi |
| collection | DOAJ |
| description | Abstract Periodontitis, one of the most prevalent dental diseases, causes the loss of bone and gum tissue that hold teeth in place. Several bacteria, commonly present in clinically healthy oral cavities, may induce and perpetuate periodontitis when their concentration rises in the gingival sulcus. Antibacterial effect against various Gram-negative and Gram-positive bacteria, including pathogenic and drug-resistant ones, has been shown for several distinct transient metal and metal oxide NPs. Therefore, NPs may be used in biomedicine to treat periodontal problems and in nanotechnology to inhibit the development of microorganisms. Instead of using harmful chemicals or energy-intensive machinery, biosynthesis of metal and metal oxide nanoparticles (NPs) has been suggested. To produce metal and metal oxide NPs, the ideal technique is “Green” synthesis because of its low toxicity and safety for human health and the environment. Gold NPs (AuNPs) appear to be less toxic to mammalian cells than other nanometals because their antibacterial activity is not dependent on reactive oxygen species (ROS). AgNPs also possess chemical stability, catalytic activity, and superior electrical and thermal conductivity, to name a few of their other advantageous characteristics. It was observed that zinc oxide (ZnO) NPs and copper (Cu) NPs exhibited discernible inhibitory effects against gram-positive and gram-negative bacterial strains, respectively. ZnO NPs demonstrated bactericidal activity against the microorganisms responsible for periodontitis. Medications containing magnetic NPs are highly effective against multidrug-resistant bacterial and fungal infections. The titanium dioxide (TiO2) NPs are implicated in elevating salivary peroxidase activity in individuals diagnosed with chronic periodontitis. Furthermore, specific metallic NPs have the potential to enhance the antimicrobial efficacy of periodontitis treatments when combined. Therefore, these NPs, as well as their oxide NPs, are only some of the metals and metal oxides that have been synthesized in environmentally friendly ways and shown to have therapeutic benefits against periodontitis. Graphical Abstract |
| first_indexed | 2024-03-08T16:14:15Z |
| format | Article |
| id | doaj.art-514c44e8ff224e08bdd9298519da56bd |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-03-08T16:14:15Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-514c44e8ff224e08bdd9298519da56bd2024-01-07T12:43:07ZengBMCJournal of Nanobiotechnology1477-31552024-01-0122113710.1186/s12951-023-02284-5Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitisMohammad Kiarashi0Parham Mahamed1Nader Ghotbi2Azadeh Tadayonfard3Kamyar Nasiri4Parisa Kazemi5Ashkan Badkoobeh6Saman Yasamineh7Ali Joudaki8College of Dentistry, Lorestan University of Medical SciencesStudent Research Committee, Alborz University of Medical SciencesGeneral Dentist, Isfahan Azad University, School of DentistryMaxillofacial prosthetics fellow, Postgraduate department of prosthodontics, Dental Faculty,Tehran University of Medical SciencesDepartment of Dentistry, Islamic Azad University of Medical SciencesFaculty of Dentistry, Ilam University of Medical SciencesDepartment of Oral and Maxillofacial Surgery, School of Dentistry, Qom University of Medical SciencesAzad ResearchersDepartment of Oral and Maxillofacial Surgery, Lorestan University of Medical SciencesAbstract Periodontitis, one of the most prevalent dental diseases, causes the loss of bone and gum tissue that hold teeth in place. Several bacteria, commonly present in clinically healthy oral cavities, may induce and perpetuate periodontitis when their concentration rises in the gingival sulcus. Antibacterial effect against various Gram-negative and Gram-positive bacteria, including pathogenic and drug-resistant ones, has been shown for several distinct transient metal and metal oxide NPs. Therefore, NPs may be used in biomedicine to treat periodontal problems and in nanotechnology to inhibit the development of microorganisms. Instead of using harmful chemicals or energy-intensive machinery, biosynthesis of metal and metal oxide nanoparticles (NPs) has been suggested. To produce metal and metal oxide NPs, the ideal technique is “Green” synthesis because of its low toxicity and safety for human health and the environment. Gold NPs (AuNPs) appear to be less toxic to mammalian cells than other nanometals because their antibacterial activity is not dependent on reactive oxygen species (ROS). AgNPs also possess chemical stability, catalytic activity, and superior electrical and thermal conductivity, to name a few of their other advantageous characteristics. It was observed that zinc oxide (ZnO) NPs and copper (Cu) NPs exhibited discernible inhibitory effects against gram-positive and gram-negative bacterial strains, respectively. ZnO NPs demonstrated bactericidal activity against the microorganisms responsible for periodontitis. Medications containing magnetic NPs are highly effective against multidrug-resistant bacterial and fungal infections. The titanium dioxide (TiO2) NPs are implicated in elevating salivary peroxidase activity in individuals diagnosed with chronic periodontitis. Furthermore, specific metallic NPs have the potential to enhance the antimicrobial efficacy of periodontitis treatments when combined. Therefore, these NPs, as well as their oxide NPs, are only some of the metals and metal oxides that have been synthesized in environmentally friendly ways and shown to have therapeutic benefits against periodontitis. Graphical Abstracthttps://doi.org/10.1186/s12951-023-02284-5Green synthesizePeriodontitisMetal oxide NanoparticlesMetal nanoparticlesAntibacterial |
| spellingShingle | Mohammad Kiarashi Parham Mahamed Nader Ghotbi Azadeh Tadayonfard Kamyar Nasiri Parisa Kazemi Ashkan Badkoobeh Saman Yasamineh Ali Joudaki Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis Journal of Nanobiotechnology Green synthesize Periodontitis Metal oxide Nanoparticles Metal nanoparticles Antibacterial |
| title | Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis |
| title_full | Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis |
| title_fullStr | Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis |
| title_full_unstemmed | Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis |
| title_short | Spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis |
| title_sort | spotlight on therapeutic efficiency of green synthesis metals and their oxide nanoparticles in periodontitis |
| topic | Green synthesize Periodontitis Metal oxide Nanoparticles Metal nanoparticles Antibacterial |
| url | https://doi.org/10.1186/s12951-023-02284-5 |
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