Prognostic Value of Podoplanin in Various Tumors
Background: The prognostic significance of podoplanin (PDPN) in tumor cells for cancer patients’ survival remains controversial. Therefore, we performed this meta-analysis to clarify the relationship between the podoplanin-positive tumor cells and cancer prognosis. Method: Eligible studies were iden...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2021-09-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338211038142 |
| _version_ | 1818737191923220480 |
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| author | Xiaohang Wang PhD Xueying Wang MS Vladmir Carvalho PhD Qianqian Wang MS Tingting Li MS Jinbang Wang PhD Yang Chen PhD Chengming Ni PhD Subo Liu BS Jiaxin Zhang MS |
| author_facet | Xiaohang Wang PhD Xueying Wang MS Vladmir Carvalho PhD Qianqian Wang MS Tingting Li MS Jinbang Wang PhD Yang Chen PhD Chengming Ni PhD Subo Liu BS Jiaxin Zhang MS |
| author_sort | Xiaohang Wang PhD |
| collection | DOAJ |
| description | Background: The prognostic significance of podoplanin (PDPN) in tumor cells for cancer patients’ survival remains controversial. Therefore, we performed this meta-analysis to clarify the relationship between the podoplanin-positive tumor cells and cancer prognosis. Method: Eligible studies were identified by searching the Pubmed and EBSCO online databases up to August 2019. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the correlation between podoplanin expression and overall survival (OS) and/or disease-free survival (DFS) and odds ratios (ORs) with 95% CIs severed as the summarized statistics for clinicopathological characteristic. Results: A total of 2155 patients from 21 eligible studies were included. The results revealed that high expression of podoplanin was associated with a poor survival rate in cancer patients. Further subgroup analysis stratified by tumor type showed that podoplanin-positive tumor cell infiltration had a negative prognostic effect associated with survival in esophageal cancer and oropharyngeal cancer. In addition, high expression of these cells was significantly associated with N stage, T stage, TNM stage and vascular invasion. Conclusion: Our study suggests the over-expression of podoplanin might be a significant prognostic indicator for patients with esophageal and oropharyngeal cancer. |
| first_indexed | 2024-12-18T00:49:08Z |
| format | Article |
| id | doaj.art-514d85f346b34736b44ec859edb50b82 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-12-18T00:49:08Z |
| publishDate | 2021-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-514d85f346b34736b44ec859edb50b822022-12-21T21:26:43ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382021-09-012010.1177/15330338211038142Prognostic Value of Podoplanin in Various TumorsXiaohang Wang PhD0Xueying Wang MS1Vladmir Carvalho PhD2Qianqian Wang MS3Tingting Li MS4Jinbang Wang PhD5Yang Chen PhD6Chengming Ni PhD7Subo Liu BS8Jiaxin Zhang MS9 Xiaohang Wang and Xueying Wang contributed equally to this article Xiaohang Wang and Xueying Wang contributed equally to this article Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China Department of Endocrinology, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing, China Department of Endocrinology, Shijiazhuang First Hospital, Shijiazhuang, China Department of Breast and Thyroid Surgery, Yangzhou University Affiliated Northern Jiangsu People's Hospital, Yangzhou, Jiangsu, ChinaBackground: The prognostic significance of podoplanin (PDPN) in tumor cells for cancer patients’ survival remains controversial. Therefore, we performed this meta-analysis to clarify the relationship between the podoplanin-positive tumor cells and cancer prognosis. Method: Eligible studies were identified by searching the Pubmed and EBSCO online databases up to August 2019. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to evaluate the correlation between podoplanin expression and overall survival (OS) and/or disease-free survival (DFS) and odds ratios (ORs) with 95% CIs severed as the summarized statistics for clinicopathological characteristic. Results: A total of 2155 patients from 21 eligible studies were included. The results revealed that high expression of podoplanin was associated with a poor survival rate in cancer patients. Further subgroup analysis stratified by tumor type showed that podoplanin-positive tumor cell infiltration had a negative prognostic effect associated with survival in esophageal cancer and oropharyngeal cancer. In addition, high expression of these cells was significantly associated with N stage, T stage, TNM stage and vascular invasion. Conclusion: Our study suggests the over-expression of podoplanin might be a significant prognostic indicator for patients with esophageal and oropharyngeal cancer.https://doi.org/10.1177/15330338211038142 |
| spellingShingle | Xiaohang Wang PhD Xueying Wang MS Vladmir Carvalho PhD Qianqian Wang MS Tingting Li MS Jinbang Wang PhD Yang Chen PhD Chengming Ni PhD Subo Liu BS Jiaxin Zhang MS Prognostic Value of Podoplanin in Various Tumors Technology in Cancer Research & Treatment |
| title | Prognostic Value of Podoplanin in Various Tumors |
| title_full | Prognostic Value of Podoplanin in Various Tumors |
| title_fullStr | Prognostic Value of Podoplanin in Various Tumors |
| title_full_unstemmed | Prognostic Value of Podoplanin in Various Tumors |
| title_short | Prognostic Value of Podoplanin in Various Tumors |
| title_sort | prognostic value of podoplanin in various tumors |
| url | https://doi.org/10.1177/15330338211038142 |
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