Cancer associated fibroblast FAK regulates malignant cell metabolism
Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast and pancreatic cancer patients and that FAK-silencin...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15104-3 |
| _version_ | 1818839209453027328 |
|---|---|
| author | Fevzi Demircioglu Jun Wang Juliana Candido Ana S. H. Costa Pedro Casado Beatriz de Luxan Delgado Louise E. Reynolds Jesus Gomez-Escudero Emma Newport Vinothini Rajeeve Ann-Marie Baker Marina Roy-Luzarraga Trevor A. Graham Julie Foster Yu Wang James J. Campbell Rajinder Singh Penglie Zhang Thomas J. Schall Frances R. Balkwill Jane Sosabowski Pedro R. Cutillas Christian Frezza Patricia Sancho Kairbaan Hodivala-Dilke |
| author_facet | Fevzi Demircioglu Jun Wang Juliana Candido Ana S. H. Costa Pedro Casado Beatriz de Luxan Delgado Louise E. Reynolds Jesus Gomez-Escudero Emma Newport Vinothini Rajeeve Ann-Marie Baker Marina Roy-Luzarraga Trevor A. Graham Julie Foster Yu Wang James J. Campbell Rajinder Singh Penglie Zhang Thomas J. Schall Frances R. Balkwill Jane Sosabowski Pedro R. Cutillas Christian Frezza Patricia Sancho Kairbaan Hodivala-Dilke |
| author_sort | Fevzi Demircioglu |
| collection | DOAJ |
| description | Cancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast and pancreatic cancer patients and that FAK-silencing in CAFs promotes tumourigenesis by the paracrine regulation of cancer cell metabolism. |
| first_indexed | 2024-12-19T03:50:39Z |
| format | Article |
| id | doaj.art-514da35f7c834a7f879f285d226a9e53 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:50:39Z |
| publishDate | 2020-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-514da35f7c834a7f879f285d226a9e532022-12-21T20:37:01ZengNature PortfolioNature Communications2041-17232020-03-0111111810.1038/s41467-020-15104-3Cancer associated fibroblast FAK regulates malignant cell metabolismFevzi Demircioglu0Jun Wang1Juliana Candido2Ana S. H. Costa3Pedro Casado4Beatriz de Luxan Delgado5Louise E. Reynolds6Jesus Gomez-Escudero7Emma Newport8Vinothini Rajeeve9Ann-Marie Baker10Marina Roy-Luzarraga11Trevor A. Graham12Julie Foster13Yu Wang14James J. Campbell15Rajinder Singh16Penglie Zhang17Thomas J. Schall18Frances R. Balkwill19Jane Sosabowski20Pedro R. Cutillas21Christian Frezza22Patricia Sancho23Kairbaan Hodivala-Dilke24Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreMRC Cancer Unit, University of Cambridge, Hutchison/MRC Research CentreCentre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Stem Cells in Cancer and Ageing, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreChemoCentryx Inc.ChemoCentryx Inc.ChemoCentryx Inc.ChemoCentryx Inc.ChemoCentryx Inc.Centre for Cancer and Inflammation, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreMRC Cancer Unit, University of Cambridge, Hutchison/MRC Research CentreCentre for Stem Cells in Cancer and Ageing, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCentre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, John Vane Science CentreCancer associated fibroblasts (CAFs) have been suggested to regulate cancer cell metabolism, but the mechanisms are not completely elucidated. Here, the authors show that low FAK expression in stromal cells correlates with poor prognosis in breast and pancreatic cancer patients and that FAK-silencing in CAFs promotes tumourigenesis by the paracrine regulation of cancer cell metabolism.https://doi.org/10.1038/s41467-020-15104-3 |
| spellingShingle | Fevzi Demircioglu Jun Wang Juliana Candido Ana S. H. Costa Pedro Casado Beatriz de Luxan Delgado Louise E. Reynolds Jesus Gomez-Escudero Emma Newport Vinothini Rajeeve Ann-Marie Baker Marina Roy-Luzarraga Trevor A. Graham Julie Foster Yu Wang James J. Campbell Rajinder Singh Penglie Zhang Thomas J. Schall Frances R. Balkwill Jane Sosabowski Pedro R. Cutillas Christian Frezza Patricia Sancho Kairbaan Hodivala-Dilke Cancer associated fibroblast FAK regulates malignant cell metabolism Nature Communications |
| title | Cancer associated fibroblast FAK regulates malignant cell metabolism |
| title_full | Cancer associated fibroblast FAK regulates malignant cell metabolism |
| title_fullStr | Cancer associated fibroblast FAK regulates malignant cell metabolism |
| title_full_unstemmed | Cancer associated fibroblast FAK regulates malignant cell metabolism |
| title_short | Cancer associated fibroblast FAK regulates malignant cell metabolism |
| title_sort | cancer associated fibroblast fak regulates malignant cell metabolism |
| url | https://doi.org/10.1038/s41467-020-15104-3 |
| work_keys_str_mv | AT fevzidemircioglu cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT junwang cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT julianacandido cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT anashcosta cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT pedrocasado cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT beatrizdeluxandelgado cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT louiseereynolds cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT jesusgomezescudero cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT emmanewport cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT vinothinirajeeve cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT annmariebaker cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT marinaroyluzarraga cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT trevoragraham cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT juliefoster cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT yuwang cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT jamesjcampbell cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT rajindersingh cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT pengliezhang cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT thomasjschall cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT francesrbalkwill cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT janesosabowski cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT pedrorcutillas cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT christianfrezza cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT patriciasancho cancerassociatedfibroblastfakregulatesmalignantcellmetabolism AT kairbaanhodivaladilke cancerassociatedfibroblastfakregulatesmalignantcellmetabolism |