The invariant chain CD74 protein is a cell surface binding partner of TIMP‐1 in breast cancer cells

The invariant chain CD74 protein is a cell surface binding partner of TIMP‐1 in breast cancer cells

Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) regulates the proteolytic activity of matrix metalloproteinases (MMPs), playing an important role in the homeostasis of the extracellular matrix. Beyond its well‐known role in tissue maintenance, TIMP‐1 has been associated with multiple MMP‐independe...

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Bibliographic Details
Main Authors: Mikkel Høeberg, Julie Boertmann Noer, Mette Vixø Vistesen, Annette Bartels, Esben Matzen Bech, Sune Boris Nygård, Ulrik Lademann, Jan Stenvang, Siqi Liu, Anja Thoe Fuglsang, Nils Brünner, José Manuel Afonso Moreira
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Molecular Oncology
Subjects:
breast cancer
cell signaling
invariant chain (CD74)
receptor
TIMP‐1 interaction
Online Access:https://doi.org/10.1002/1878-0261.13436

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