Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia
Current evidence indicates that postischemic brain injury is associated with the accumulation of folding proteins, such as amyloid and tau protein, in the intra- and extracellular spaces of neuronal cells. In this review, we summarize protein changes associated with Alzheimer’s disease and their gen...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/13/4599 |
| _version_ | 1797563871884476416 |
|---|---|
| author | Ryszard Pluta Marzena Ułamek-Kozioł Sławomir Januszewski Stanisław J. Czuczwar |
| author_facet | Ryszard Pluta Marzena Ułamek-Kozioł Sławomir Januszewski Stanisław J. Czuczwar |
| author_sort | Ryszard Pluta |
| collection | DOAJ |
| description | Current evidence indicates that postischemic brain injury is associated with the accumulation of folding proteins, such as amyloid and tau protein, in the intra- and extracellular spaces of neuronal cells. In this review, we summarize protein changes associated with Alzheimer’s disease and their gene expression (amyloid protein precursor and tau protein) after brain ischemia, and their roles in the postischemic period. Recent advances in understanding the postischemic mechanisms in development of neurodegeneration have revealed dysregulation of amyloid protein precursor, α-, β- and γ-secretase and tau protein genes. Reduced expression of the α-secretase gene after brain ischemia with recirculation causes neuronal cells to be less resistant to injury. We present the latest data that Alzheimer’s disease-related proteins and their genes play a crucial role in postischemic neurodegeneration. Understanding the underlying processes of linking Alzheimer’s disease-related proteins and their genes in development of postischemic neurodegeneration will provide the most significant goals to date for therapeutic development. |
| first_indexed | 2024-03-10T18:49:19Z |
| format | Article |
| id | doaj.art-514dd83312b947dbb52afd603097264a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:49:19Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-514dd83312b947dbb52afd603097264a2023-11-20T05:14:18ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-06-012113459910.3390/ijms21134599Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain IschemiaRyszard Pluta0Marzena Ułamek-Kozioł1Sławomir Januszewski2Stanisław J. Czuczwar3Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, PolandLaboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, PolandLaboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Centre, Polish Academy of Sciences, 02-106 Warsaw, PolandDepartment of Pathophysiology, Medical University of Lublin, 20-090 Lublin, PolandCurrent evidence indicates that postischemic brain injury is associated with the accumulation of folding proteins, such as amyloid and tau protein, in the intra- and extracellular spaces of neuronal cells. In this review, we summarize protein changes associated with Alzheimer’s disease and their gene expression (amyloid protein precursor and tau protein) after brain ischemia, and their roles in the postischemic period. Recent advances in understanding the postischemic mechanisms in development of neurodegeneration have revealed dysregulation of amyloid protein precursor, α-, β- and γ-secretase and tau protein genes. Reduced expression of the α-secretase gene after brain ischemia with recirculation causes neuronal cells to be less resistant to injury. We present the latest data that Alzheimer’s disease-related proteins and their genes play a crucial role in postischemic neurodegeneration. Understanding the underlying processes of linking Alzheimer’s disease-related proteins and their genes in development of postischemic neurodegeneration will provide the most significant goals to date for therapeutic development.https://www.mdpi.com/1422-0067/21/13/4599brain ischemiaamyloidtau proteinsecretasespresenilinneuronal death |
| spellingShingle | Ryszard Pluta Marzena Ułamek-Kozioł Sławomir Januszewski Stanisław J. Czuczwar Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia International Journal of Molecular Sciences brain ischemia amyloid tau protein secretases presenilin neuronal death |
| title | Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia |
| title_full | Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia |
| title_fullStr | Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia |
| title_full_unstemmed | Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia |
| title_short | Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia |
| title_sort | participation of amyloid and tau protein in neuronal death and neurodegeneration after brain ischemia |
| topic | brain ischemia amyloid tau protein secretases presenilin neuronal death |
| url | https://www.mdpi.com/1422-0067/21/13/4599 |
| work_keys_str_mv | AT ryszardpluta participationofamyloidandtauproteininneuronaldeathandneurodegenerationafterbrainischemia AT marzenaułamekkozioł participationofamyloidandtauproteininneuronaldeathandneurodegenerationafterbrainischemia AT sławomirjanuszewski participationofamyloidandtauproteininneuronaldeathandneurodegenerationafterbrainischemia AT stanisławjczuczwar participationofamyloidandtauproteininneuronaldeathandneurodegenerationafterbrainischemia |