Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies
Background: Patients with obsessive compulsive disorder (OCD) often show deficits in inhibitory control, which may underlie poor control over obsessions and compulsions. Several functional magnetic resonance imaging (fMRI) experiments utilizing a variety of tasks have investigated the neural correla...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-01-01
|
| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222003333 |
| _version_ | 1811307429680381952 |
|---|---|
| author | Valdemar Funch Uhre Kit Melissa Larsen Damian Marc Herz William Baaré Anne Katrine Pagsberg Hartwig Roman Siebner |
| author_facet | Valdemar Funch Uhre Kit Melissa Larsen Damian Marc Herz William Baaré Anne Katrine Pagsberg Hartwig Roman Siebner |
| author_sort | Valdemar Funch Uhre |
| collection | DOAJ |
| description | Background: Patients with obsessive compulsive disorder (OCD) often show deficits in inhibitory control, which may underlie poor control over obsessions and compulsions. Several functional magnetic resonance imaging (fMRI) experiments utilizing a variety of tasks have investigated the neural correlates of inhibitory control in OCD. Evidence from existing meta-analyses suggests aberrant activation of regions in fronto-striatal circuits during inhibitory control. However, new fMRI articles have since been published, and a more rigorous methodology for neuroimaging meta-analyses is now available. Objectives: First, to reevaluate the evidence for abnormal brain activation during performance of inhibitory control tasks in OCD while adhering to current best practices for meta-analyses, and second, to extend previous findings by separately assessing different subprocesses of inhibitory control. Method: We systematically searched Web of Knowledge, ScienceDirect, Scopus, PubMed and the functional BrainMap database for fMRI articles that compared activation during performance of inhibitory control tasks in patients with OCD and healthy control (HC) subjects. Thirty-five experiments from 21 articles met our criteria for inclusion. We first performed activation-likelihood-estimation meta-analyses to elucidate brain areas in which case-control activation differences converged across articles and tasks. We then aimed to extend previous work by separately evaluating experiments requiring inhibition of a prepotent response without execution of an alternative response (i.e., response inhibition) and experiments requiring inhibition of a prepotent response and execution of an alternative response (i.e., cognitive inhibition). Results: The 35 experiments included a total of 394 patients and 410 controls. We did not find evidence of abnormal brain activation in OCD during inhibitory control when pooling data from all experiments. Analysis restricted to cognitive inhibition experiments showed abnormal activation of the dorsal anterior cingulate cortex (dACC; P = .04, cluster-level familywise error-corrected, cluster volume of 824 mm3). We did not have sufficient data to evaluate response inhibition experiments separately. Conclusion: Findings of abnormal brain activation in OCD from different inhibitory control tasks do not appear to converge on the same brain regions, but the dACC may be implicated in abnormal cognitive inhibition. Our findings highlight a need for experiments that specifically target subprocesses of inhibitory control to achieve a more differentiated understanding of the neural correlates for impaired inhibitory control in OCD. |
| first_indexed | 2024-04-13T09:04:13Z |
| format | Article |
| id | doaj.art-514ed77edf4a4e6d99c113c343fc3ee9 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-13T09:04:13Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-514ed77edf4a4e6d99c113c343fc3ee92022-12-22T02:53:02ZengElsevierNeuroImage: Clinical2213-15822022-01-0136103268Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studiesValdemar Funch Uhre0Kit Melissa Larsen1Damian Marc Herz2William Baaré3Anne Katrine Pagsberg4Hartwig Roman Siebner5Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Denmark; Child and Adolescent Mental Health Centre, Mental Health Services, Denmark; Corresponding author at: Danish Research Centre for Magnetic Resonance (DRCMR), section 714, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital – Amager and Hvidovre, Kettegård Allé 30, 2650 Hvidovre, Denmark.Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Child and Adolescent Mental Health Centre, Mental Health Services, DenmarkMRC Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, UK; Department of Neurology, Section Movement Disorders and Neurostimulation, University Hospital, Johannes Gutenberg University, Mainz, GermanyDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, DenmarkDepartment of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Denmark; Child and Adolescent Mental Health Centre, Mental Health Services, DenmarkDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Denmark; Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, DenmarkBackground: Patients with obsessive compulsive disorder (OCD) often show deficits in inhibitory control, which may underlie poor control over obsessions and compulsions. Several functional magnetic resonance imaging (fMRI) experiments utilizing a variety of tasks have investigated the neural correlates of inhibitory control in OCD. Evidence from existing meta-analyses suggests aberrant activation of regions in fronto-striatal circuits during inhibitory control. However, new fMRI articles have since been published, and a more rigorous methodology for neuroimaging meta-analyses is now available. Objectives: First, to reevaluate the evidence for abnormal brain activation during performance of inhibitory control tasks in OCD while adhering to current best practices for meta-analyses, and second, to extend previous findings by separately assessing different subprocesses of inhibitory control. Method: We systematically searched Web of Knowledge, ScienceDirect, Scopus, PubMed and the functional BrainMap database for fMRI articles that compared activation during performance of inhibitory control tasks in patients with OCD and healthy control (HC) subjects. Thirty-five experiments from 21 articles met our criteria for inclusion. We first performed activation-likelihood-estimation meta-analyses to elucidate brain areas in which case-control activation differences converged across articles and tasks. We then aimed to extend previous work by separately evaluating experiments requiring inhibition of a prepotent response without execution of an alternative response (i.e., response inhibition) and experiments requiring inhibition of a prepotent response and execution of an alternative response (i.e., cognitive inhibition). Results: The 35 experiments included a total of 394 patients and 410 controls. We did not find evidence of abnormal brain activation in OCD during inhibitory control when pooling data from all experiments. Analysis restricted to cognitive inhibition experiments showed abnormal activation of the dorsal anterior cingulate cortex (dACC; P = .04, cluster-level familywise error-corrected, cluster volume of 824 mm3). We did not have sufficient data to evaluate response inhibition experiments separately. Conclusion: Findings of abnormal brain activation in OCD from different inhibitory control tasks do not appear to converge on the same brain regions, but the dACC may be implicated in abnormal cognitive inhibition. Our findings highlight a need for experiments that specifically target subprocesses of inhibitory control to achieve a more differentiated understanding of the neural correlates for impaired inhibitory control in OCD.http://www.sciencedirect.com/science/article/pii/S2213158222003333Response inhibitionCognitive inhibitionfMRIOCDAnterior cingulate cortexInhibitory control |
| spellingShingle | Valdemar Funch Uhre Kit Melissa Larsen Damian Marc Herz William Baaré Anne Katrine Pagsberg Hartwig Roman Siebner Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies NeuroImage: Clinical Response inhibition Cognitive inhibition fMRI OCD Anterior cingulate cortex Inhibitory control |
| title | Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies |
| title_full | Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies |
| title_fullStr | Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies |
| title_full_unstemmed | Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies |
| title_short | Inhibitory control in obsessive compulsive disorder: A systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies |
| title_sort | inhibitory control in obsessive compulsive disorder a systematic review and activation likelihood estimation meta analysis of functional magnetic resonance imaging studies |
| topic | Response inhibition Cognitive inhibition fMRI OCD Anterior cingulate cortex Inhibitory control |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222003333 |
| work_keys_str_mv | AT valdemarfunchuhre inhibitorycontrolinobsessivecompulsivedisorderasystematicreviewandactivationlikelihoodestimationmetaanalysisoffunctionalmagneticresonanceimagingstudies AT kitmelissalarsen inhibitorycontrolinobsessivecompulsivedisorderasystematicreviewandactivationlikelihoodestimationmetaanalysisoffunctionalmagneticresonanceimagingstudies AT damianmarcherz inhibitorycontrolinobsessivecompulsivedisorderasystematicreviewandactivationlikelihoodestimationmetaanalysisoffunctionalmagneticresonanceimagingstudies AT williambaare inhibitorycontrolinobsessivecompulsivedisorderasystematicreviewandactivationlikelihoodestimationmetaanalysisoffunctionalmagneticresonanceimagingstudies AT annekatrinepagsberg inhibitorycontrolinobsessivecompulsivedisorderasystematicreviewandactivationlikelihoodestimationmetaanalysisoffunctionalmagneticresonanceimagingstudies AT hartwigromansiebner inhibitorycontrolinobsessivecompulsivedisorderasystematicreviewandactivationlikelihoodestimationmetaanalysisoffunctionalmagneticresonanceimagingstudies |