Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy

Synthesis, characterization, and evaluation of mPEG–SN38 and mPEG–PLA–SN38 micelles for cancer therapy

Jing Xie,1 Xiaomin Zhang,2 Meiyu Teng,1 Bo Yu,2 Shuang Yang,1 Robert J Lee,1,3 Lesheng Teng1 1College of Life Sciences, Jilin University, Changchun, 2Hangzhou PushiKang Biotechnology Co., Ltd, Hangzhou, People’s Republic of China; 3Division of Pharmaceutics, College of Pharmacy, The Ohio...

Full description

Bibliographic Details
Main Authors:	Xie J, Zhang X, Teng M, Yu B, Yang S, Lee RJ, Teng L
Format:	Article
Language:	English
Published:	Dove Medical Press 2016-04-01
Series:	International Journal of Nanomedicine
Subjects:	SN38 polymer conjugate micelles chemotherapy liver cancer
Online Access:	https://www.dovepress.com/synthesis-characterization-and-evaluation-of-mpegndashsn38-and-mpegnda-peer-reviewed-article-IJN

Similar Items

PEGylation of lipophilic SN38 prodrug with DSPE-mPEG2000 versus cremophor EL: comparative study for intravenous chemotherapy
by: Jun Zeng, et al.
Published: (2019-01-01)

Drug-interactive mPEG-b-PLA-Phe(Boc) micelles enhance the tolerance and anti-tumor efficacy of docetaxel
by: Feirong Gong, et al.
Published: (2020-01-01)

mPEG-PLA/TPGS mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus
by: Yu A, et al.
Published: (2017-11-01)

Preparation of Lycopene Micelles with Different Block Ratios of mPEG-PLA as Carriers and the Solubilization and Controlled Release of Lycopene Isomers
by: Chuantian LI, et al.
Published: (2023-09-01)

Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy
by: Sams M. A. Sadat, et al.
Published: (2020-10-01)

mPEG-PDLLA Micelles Potentiate Docetaxel for Intraperitoneal Chemotherapy in Ovarian Cancer Peritoneal Metastasis
by: Yumei Zhang, et al.
Published: (2022-04-01)

Self-assembled mPEG&ndash;PCL-g&ndash;PEI micelles for simultaneous codelivery of chemotherapeutic drugs and DNA: synthesis and characterization in vitro
by: Shi S, et al.
Published: (2012-03-01)

Enhanced Anticancer Activity of 5’-DFUR-PCL-MPEG Polymeric Prodrug Micelles Encapsulating Chemotherapeutic Drugs
by: Alicia J. Sawdon, et al.
Published: (2018-12-01)

ROS-sensitive calcipotriol nano-micelles prepared by methoxypolyethylene glycol (mPEG) – modified polymer for the treatment of psoriasis
by: Yulin Hua, et al.
Published: (2022-12-01)

Redox-Responsive Disulfide Bond-Bridged mPEG-PBLA Prodrug Micelles for Enhanced Paclitaxel Biosafety and Antitumor Efficacy
by: Sheng Chang, et al.
Published: (2019-08-01)

Acetal-Linked Paclitaxel Polymeric Prodrug Based on Functionalized mPEG-PCL Diblock Polymer for pH-Triggered Drug Delivery
by: Yinglei Zhai, et al.
Published: (2017-12-01)

Targeted delivery by pH-responsive mPEG-S-PBLG micelles significantly enhances the anti-tumor efficacy of doxorubicin with reduced cardiotoxicity
by: Qiyi Feng, et al.
Published: (2021-01-01)

Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy
by: Bi Y, et al.
Published: (2018-10-01)

Tetracycline-grafted mPEG-PLGA micelles for bone-targeting and osteoporotic improvement
by: Yunduan Que, et al.
Published: (2022-09-01)

Docetaxel loaded mPEG-PLA nanoparticles for sarcoma therapy: preparation, characterization, pharmacokinetics, and anti-tumor efficacy
by: Jianhua Chen, et al.
Published: (2021-01-01)

Cholesterol-Inulin Conjugates for Efficient SN38 Nuclear Delivery: Nanomedicines for Precision Cancer Therapy
by: Nicolò Mauro, et al.
Published: (2022-10-01)

Synthesis and evaluation of highly releasable and structurally stable antibody-SN-38-conjugates
by: Lianqi Liu, et al.
Published: (2021-01-01)

Stabilization of resveratrol in blood circulation by conjugation to mPEG and mPEG-PLA polymers: investigation of conjugate linker and polymer composition on stability, metabolism, antioxidant activity and pharmacokinetic profile.
by: Basavaraj Siddalingappa, et al.
Published: (2015-01-01)

Research Progress of SN38 Drug Delivery System in Cancer Treatment
by: Qi QR, et al.
Published: (2024-01-01)

mPEG-icariin nanoparticles for treating myocardial ischaemia
by: Yongqiang Zheng, et al.
Published: (2019-12-01)

Tuning Size and Morphology of mPEG-<i>b</i>-p(HPMA-Bz) Copolymer Self-Assemblies Using Microfluidics
by: Jaleesa Bresseleers, et al.
Published: (2020-11-01)

Single protein encapsulated SN38 for tumor-targeting treatment
by: Changjun Yu, et al.
Published: (2023-12-01)

Inhibitory effects of NSAID-conjugated SN-38 on the viability of A549 Non-small cell lung cancer cells
by: Hae–Won Kwon, et al.
Published: (2023-09-01)

Synthesis of new biodegradable nanocarriers for SN38 delivery and synergistic phototherapy
by: Elham Einafshar, et al.
Published: (2018-10-01)

Ultrasound-triggered with ROS-responsive SN38 nanoparticle for enhanced combination cancer immunotherapy
by: Hongyu Liu, et al.
Published: (2024-03-01)

Comparing Zwitterionic and PEG Exteriors of Polyelectrolyte Complex Micelles
by: Jeffrey M. Ting, et al.
Published: (2020-05-01)

Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs
by: Mo Zhou, et al.
Published: (2014-11-01)

Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG&ndash;PLA micelle
by: Shi YN, et al.
Published: (2012-12-01)

Evaluation of mPEG-PLA nanoparticles as vaccine delivery system for modified protective antigen of Bacillus anthracis
by: Seyed Masih Etemad aubi, et al.
Published: (2021-10-01)

Light- and Redox-Responsive Block Copolymers of mPEG-SS-ONBMA as a Smart Drug Delivery Carrier for Cancer Therapy
by: Yu-Lun Lo, et al.
Published: (2022-11-01)

Dual-Functional Polymeric Micelles Co-Loaded with Antineoplastic Drugs and Tyrosine Kinase Inhibitor for Combination Therapy in Colorectal Cancer
by: Ying-Hsia Shih, et al.
Published: (2022-03-01)

mPEG-PLGA Nanoparticles Labelled with Loaded or Conjugated Rhodamine-B for Potential Nose-to-Brain Delivery
by: Emanuela Fabiola Craparo, et al.
Published: (2021-09-01)

Thermo-Sensitive mPEG-PA-PLL Hydrogel for Drug Release of Calcitonin
by: Yu-En Cheng, et al.
Published: (2022-05-01)

Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content
by: Avgoustakis K, et al.
Published: (2012-03-01)

Smart stimuli-responsive carrier-free nanoassembly of SN38 prodrug as efficient chemotherapeutic nanomedicine
by: Guanting Li, et al.
Published: (2023-02-01)

Novel lipophilic SN38 prodrug forming stable liposomes for colorectal carcinoma therapy
by: Xing J, et al.
Published: (2019-07-01)

A feasible strategy of fabricating camptothecin (SN38)-loaded holmium ferrite nanocarrier delivery for glioma treatment
by: Yu Zeng, et al.
Published: (2022-01-01)

Carbon dots conjugated to SN38 for improved colorectal anticancer therapy
by: Deborah Mattinzoli, et al.
Published: (2022-12-01)

Cisplatin-loaded mPEG-PCL Nanoparticles: Relation of PEG-PCL/PCL Hybrid Proportions and Antitumor Activity in Vitro
by: WANG Chun, et al.
Published: (2020-06-01)

Amphiphilic mPEG-Modified Oligo-Phenylalanine Nanoparticles Chemoenzymatically Synthesized via Papain
by: Feng Wang, et al.
Published: (2020-11-01)