Gut Microbiome-Linked Metabolites in the Pathobiology of Major Depression With or Without Anxiety—A Role for Bile Acids

Gut Microbiome-Linked Metabolites in the Pathobiology of Major Depression With or Without Anxiety—A Role for Bile Acids

BackgroundThe gut microbiome may play a role in the pathogenesis of neuropsychiatric diseases including major depressive disorder (MDD). Bile acids (BAs) are steroid acids that are synthesized in the liver from cholesterol and further processed by gut-bacterial enzymes, thus requiring both human and...

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Bibliographic Details
Main Authors: Siamak MahmoudianDehkordi, Sudeepa Bhattacharyya, Christopher R. Brydges, Wei Jia, Oliver Fiehn, A. John Rush, Boadie W. Dunlop, Rima Kaddurah-Daouk
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Neuroscience
Subjects:
metabolomics
gut microbiome
bile acids
anxiety
depression
major depressive disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.937906/full

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