Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus

Astrocytic Atrophy Following Status Epilepticus Parallels Reduced Ca2+ Activity and Impaired Synaptic Plasticity in the Rat Hippocampus

Epilepsy is a group of neurological disorders commonly associated with the neuronal malfunction leading to generation of seizures. Recent reports point to a possible contribution of astrocytes into this pathology. We used the lithium-pilocarpine model of status epilepticus (SE) in rats to monitor ch...

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Bibliographic Details
Main Authors: Alex Plata, Albina Lebedeva, Pavel Denisov, Olga Nosova, Tatiana Y. Postnikova, Alexey Pimashkin, Alexey Brazhe, Aleksey V. Zaitsev, Dmitri A. Rusakov, Alexey Semyanov
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
astrocyte remodeling
epilepsy
D-serine
calcium
plasticity
spatial entropy
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00215/full

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