Engineering Strategies in Microorganisms for the Enhanced Production of Squalene: Advances, Challenges and Opportunities

Engineering Strategies in Microorganisms for the Enhanced Production of Squalene: Advances, Challenges and Opportunities

The triterpene squalene is a natural compound that has demonstrated an extraordinary diversity of uses in pharmaceutical, nutraceutical, and personal care industries. Emboldened by this range of uses, novel applications that can gain profit from the benefits of squalene as an additive or supplement...

Полное описание

Библиографические подробности
Главные авторы:	Nisarg Gohil, Gargi Bhattacharjee, Khushal Khambhati, Darren Braddick, Vijai Singh
Формат:	Статья
Язык:	English
Опубликовано:	Frontiers Media S.A. 2019-03-01
Серии:	Frontiers in Bioengineering and Biotechnology
Предметы:	squalene metabolic engineering fermentation biosynthesis production synthetic biology
Online-ссылка:	https://www.frontiersin.org/article/10.3389/fbioe.2019.00050/full

Схожие документы

Corrigendum: Engineering Strategies in Microorganisms for the Enhanced Production of Squalene: Advances, Challenges and Opportunities
по: Nisarg Gohil, и др.
Опубликовано: (2019-05-01)

Squalene Biosynthesis in Engineered <i>Escherichia Coli</i>
по: Wei Zhang, и др.
Опубликовано: (2023-12-01)

Introduction of a green algal squalene synthase enhances squalene accumulation in a strain of Synechocystis sp. PCC 6803
по: Bagmi Pattanaik, и др.
Опубликовано: (2020-06-01)

Squalene synthase cloning and functional identification in wintersweet plant (Chimonanthus zhejiangensis)
по: Guanhua Liu, и др.
Опубликовано: (2018-12-01)

Methods for Squalene Concentration from Palm Fatty Acid Distillate
по: Chua, Camilla Soo Leng
Опубликовано: (2007)

Microbial Squalene: A Sustainable Alternative for the Cosmetics and Pharmaceutical Industry – A Review
по: Saseendran Shalu, и др.
Опубликовано: (2024-10-01)

Molecular characterization and transcriptional regulation analysis of the Torreya grandis squalene synthase gene involved in sitosterol biosynthesis and drought response
по: Feicui Zhang, и др.
Опубликовано: (2023-06-01)

Investigation of the Formation of Squalene Oligomers Exposed to Ultraviolet Light and Changes in the Exposed Squalene as a Potential Skin Model
по: Matteo Zecchini, и др.
Опубликовано: (2022-05-01)

Strategies to Better Target Fungal Squalene Monooxygenase
по: Alia A. Sagatova
Опубликовано: (2021-01-01)

Downregulation of Squalene Synthase Broadly Impacts Isoprenoid Biosynthesis in Guayule
по: Dante Placido, и др.
Опубликовано: (2022-03-01)

Identification of reference genes via real-time quantitative PCR for investigation of the transcriptomic basis of the squalene biosynthesis in different tissues on olives under drought stress
по: Haiyang Chi, и др.
Опубликовано: (2024-12-01)

Rebooting life: engineering non-natural nucleic acids, proteins and metabolites in microorganisms
по: Shriya Hans, и др.
Опубликовано: (2022-05-01)

Biosynthesis of presqualene pyrophosphate by liver microsomes
по: H.C. RILLING
Опубликовано: (1970-09-01)

Squalene Emulsions for Parenteral Vaccine and Drug Delivery
по: Christopher B. Fox
Опубликовано: (2009-09-01)

Analysis of Antidiabetic Activity of Squalene via In Silico and In Vivo Assay
по: Tri Widyawati, и др.
Опубликовано: (2023-04-01)

Formulation, characterization and in vitro bioaccessibility evaluation of mixed soy lecithin-based squalene liposome-encapsulated quercetin with added phytosterols
по: Pakbaten Toopkanloo, Sahar
Опубликовано: (2020)

A rapid method for squalene determination in vegetable oils
по: A. Lanzón, и др.
Опубликовано: (1995-10-01)

Structural and Molecular Characterization of Squalene Synthase Belonging to the Marine Thraustochytrid Species <i>Aurantiochytrium limacinum</i> Using Bioinformatics Approach
по: Sachin Vyas, и др.
Опубликовано: (2022-02-01)

Identifikasi kandungan Squalene dari Minyak Nyamplung (calophyllum inophyllum)
по: Teguh Saputra, и др.
Опубликовано: (2014-09-01)

A squalene epoxidase from Nigella sativa participates in saponin biosynthesis and mediates terbinafine resistance in yeast
по: Lipinski Marta, и др.
Опубликовано: (2009-06-01)

Molecular Identification of Native Strain of Thraustochytrium 71-1 and Qualitative and Quantitative Determination of Produced Total Oil and its Squalene
по: farshad khoshbasirat, и др.
Опубликовано: (2019-03-01)

Green Microalgae Strain Improvement for the Production of Sterols and Squalene
по: Supakorn Potijun, и др.
Опубликовано: (2021-08-01)

Squalene monooxygenase (SQLE) protects ovarian cancer cells from ferroptosis
по: Rong Zhang, и др.
Опубликовано: (2024-09-01)

Extraction of squalene from palm oil mesocarp using supercritical carbon dioxide /
по: Chen, Xiao Long, 1989- author, и др.
Опубликовано: (2014)

Anti-inflammatory activities of squalene compound of methanol extract of Abroma augusta L
по: Madyawati Latief, и др.
Опубликовано: (2020-12-01)

Microwave-assisted protocol for squalene isolation and conversion from oil-deodoriser distillates
по: Bucciol Fabio, и др.
Опубликовано: (2019-01-01)

A comprehensive analysis of Italian web pages mentioning squalene-based influenza vaccine adjuvants reveals a high prevalence of misinformation
по: Donatella Panatto, и др.
Опубликовано: (2018-04-01)

Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages
по: Ana Cárdeno, и др.
Опубликовано: (2015-04-01)

Squalene Peroxidation and Biophysical Parameters in Acne-Prone Skin: A Pilot “In Vivo” Study
по: Giorgia Condrò, и др.
Опубликовано: (2023-12-01)

Nanowire-based squalene oleogel repairs skin photoaging
по: Li Yan, и др.
Опубликовано: (2025-02-01)

Squalene: More than a Step toward Sterols
по: Marco Micera, и др.
Опубликовано: (2020-08-01)

From Sharks to Yeasts: Squalene in the Development of Vaccine Adjuvants
по: Adélia Mendes, и др.
Опубликовано: (2022-02-01)

Interdependence of Anti-Inflammatory and Antioxidant Properties of Squalene–Implication for Cardiovascular Health
по: Nurul ‘Izzah Ibrahim, и др.
Опубликовано: (2021-01-01)

Squalene recovery from palm fatty acid distillate using pressure swing and conventional supercritical carbon dioxide extraction
по: Suleiman, Norhidayah
Опубликовано: (2011)

Extraction of squalene from palm oil mesocarp using supercritical carbon dioxide [electronic resource] /
по: Chen, Xiao Long, 1989-
Опубликовано: (2014)

Dietary squalene supplementation alleviates diquat-induced oxidative stress and liver damage of broiler chickens
по: Y.P. Chen, и др.
Опубликовано: (2021-03-01)

Development of a vaccine adjuvant based on squalene and study of its adjuvant properties
по: E. A. Volosnikova, и др.
Опубликовано: (2023-06-01)

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase
по: Hudson W Coates, и др.
Опубликовано: (2023-01-01)

Squalene Cyclases and Cycloartenol Synthases from Polystichum polyblepharum and Six Allied Ferns
по: Junichi Shinozaki, и др.
Опубликовано: (2018-07-01)

Dichotomy in Neutralizing Antibody Induction to Peptide-Conjugated Vaccine in Squalene Emulsion Contrast With Aluminum Hydroxide Formulation
по: Olivia Bonduelle, и др.
Опубликовано: (2022-04-01)