(+)-9-Trifluoroethoxy-α-Dihydrotetrabenazine as a Highly Potent Vesicular Monoamine Transporter 2 Inhibitor for Tardive Dyskinesia

(+)-9-Trifluoroethoxy-α-Dihydrotetrabenazine as a Highly Potent Vesicular Monoamine Transporter 2 Inhibitor for Tardive Dyskinesia

Valbenazine and deutetrabenazine are the only two therapeutic drugs approved for tardive dyskinesia based on blocking the action of vesicular monoamine transporter 2 (VMAT2). But there exist demethylated inactive metabolism at the nine position for both them resulting in low availability, and CYP2D6...

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Detalles Bibliográficos
Main Authors: Wenyan Wang, Guangying Du, Shilan Lin, Jing Liu, Huijie Yang, Dawei Yu, Liang Ye, Fangxia Zou, Hongbo Wang, Rui Zhang, Jingwei Tian
Formato: Artigo
Idioma:English
Publicado: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Pharmacology
Subjects:
vesicular monoamine transporter 2
dihydrotetrabenazine
DA uptake
tardive dyskinesia
metabolite identification
metabolic enzyme phenotype
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fphar.2021.770377/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.770377/full

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