Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART
Abstract Background HIV clinical presentation in the acute stage is variable and some of its virological and immunological aspects are not completely understood. Most cases of HIV- associated reactive hemophagocytic syndrome have been reported in patients with advanced stages of HIV and to our knowl...
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| Format: | Article |
| Language: | English |
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BMC
2016-10-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-016-1945-9 |
| _version_ | 1818891225363644416 |
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| author | Rita Veiga Ferraz Ana Cláudia Carvalho Fernando Araújo Carmo Koch Cândida Abreu António Sarmento |
| author_facet | Rita Veiga Ferraz Ana Cláudia Carvalho Fernando Araújo Carmo Koch Cândida Abreu António Sarmento |
| author_sort | Rita Veiga Ferraz |
| collection | DOAJ |
| description | Abstract Background HIV clinical presentation in the acute stage is variable and some of its virological and immunological aspects are not completely understood. Most cases of HIV- associated reactive hemophagocytic syndrome have been reported in patients with advanced stages of HIV and to our knowledge, there are only 8 cases in the English literature presenting during acute HIV infection, most in East Asia, being this the first case in a European patient. Case presentation We report a case of a European Caucasian 27- year old woman with a primary HIV- infection presenting with extremely low CD4+ T cell count who developed a haemophagocytic syndrome after starting ART and in whom we documented a very unusual serological and virological response, characterized by an impaired HIV- antibody production and a 12 month time frame to reach an undetectable viral load, despite no evidence of resistance. Conclusions This case report apart from describing an unusual clinical presentation of an acute HIV infection as hemophagocytic syndrome provides useful information that might contribute for understanding some subtle issues in acute HIV infection, namely the dynamics of virological and immunological aspects after antiretroviral therapy initiation. |
| first_indexed | 2024-12-19T17:37:25Z |
| format | Article |
| id | doaj.art-5155e5dc75ff47a9a070336af4662069 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-19T17:37:25Z |
| publishDate | 2016-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-5155e5dc75ff47a9a070336af46620692022-12-21T20:12:18ZengBMCBMC Infectious Diseases1471-23342016-10-011611510.1186/s12879-016-1945-9Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ARTRita Veiga Ferraz0Ana Cláudia Carvalho1Fernando Araújo2Carmo Koch3Cândida Abreu4António Sarmento5Infectious Diseases Department, Centro Hospitalar de São JoãoInfectious Diseases Department, Centro Hospitalar de São JoãoTransfusion Medicine and Hematology Department, Centro Hospitalar de São JoãoTransfusion Medicine and Hematology Department, Centro Hospitalar de São JoãoInfectious Diseases Department, Centro Hospitalar de São JoãoInfectious Diseases Department, Centro Hospitalar de São JoãoAbstract Background HIV clinical presentation in the acute stage is variable and some of its virological and immunological aspects are not completely understood. Most cases of HIV- associated reactive hemophagocytic syndrome have been reported in patients with advanced stages of HIV and to our knowledge, there are only 8 cases in the English literature presenting during acute HIV infection, most in East Asia, being this the first case in a European patient. Case presentation We report a case of a European Caucasian 27- year old woman with a primary HIV- infection presenting with extremely low CD4+ T cell count who developed a haemophagocytic syndrome after starting ART and in whom we documented a very unusual serological and virological response, characterized by an impaired HIV- antibody production and a 12 month time frame to reach an undetectable viral load, despite no evidence of resistance. Conclusions This case report apart from describing an unusual clinical presentation of an acute HIV infection as hemophagocytic syndrome provides useful information that might contribute for understanding some subtle issues in acute HIV infection, namely the dynamics of virological and immunological aspects after antiretroviral therapy initiation.http://link.springer.com/article/10.1186/s12879-016-1945-9HIVAcute infectionHaemophagocytic syndrome |
| spellingShingle | Rita Veiga Ferraz Ana Cláudia Carvalho Fernando Araújo Carmo Koch Cândida Abreu António Sarmento Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART BMC Infectious Diseases HIV Acute infection Haemophagocytic syndrome |
| title | Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART |
| title_full | Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART |
| title_fullStr | Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART |
| title_full_unstemmed | Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART |
| title_short | Acute HIV infection presenting as hemophagocytic syndrome with an unusual serological and virological response to ART |
| title_sort | acute hiv infection presenting as hemophagocytic syndrome with an unusual serological and virological response to art |
| topic | HIV Acute infection Haemophagocytic syndrome |
| url | http://link.springer.com/article/10.1186/s12879-016-1945-9 |
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