Quantification of Empty, Partially Filled and Full Adeno-Associated Virus Vectors Using Mass Photometry

Quantification of Empty, Partially Filled and Full Adeno-Associated Virus Vectors Using Mass Photometry

Adeno-associated viruses (AAV) are one of the most commonly used vehicles in gene therapies for the treatment of rare diseases. During the AAV manufacturing process, particles with little or no genetic material are co-produced alongside the desired AAV capsid containing the transgene of interest. Be...

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Bibliographic Details
Main Authors: Christina Wagner, Felix F. Fuchsberger, Bernd Innthaler, Martin Lemmerer, Ruth Birner-Gruenberger
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
adeno-associated virus vectors
partially filled particles
single-molecule mass photometry
genomic cargo
analytical ultracentrifugation
Online Access:https://www.mdpi.com/1422-0067/24/13/11033

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