Mathematical Simulation of Bio-Heat Transfer in Tissues Having Five Layers in the Presence of a Tumor Zone
A presence of tumor zones within biological tissues can be defined during the analysis of the skin surface temperature. This research is devoted to mathematical simulation of the time-dependent bio-heat transfer in tissues under a tumor influence. The one-dimensional partial differential equation of...
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| Format: | Article |
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MDPI AG
2024-02-01
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| Series: | Mathematics |
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| Online Access: | https://www.mdpi.com/2227-7390/12/5/676 |
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| author | Dayana V. Akulova Mikhail A. Sheremet |
| author_facet | Dayana V. Akulova Mikhail A. Sheremet |
| author_sort | Dayana V. Akulova |
| collection | DOAJ |
| description | A presence of tumor zones within biological tissues can be defined during the analysis of the skin surface temperature. This research is devoted to mathematical simulation of the time-dependent bio-heat transfer in tissues under a tumor influence. The one-dimensional partial differential equation of the Pennes model has been used for description of bio-heat transfer within the biological tissue with five layers, namely, epidermis, papillary dermis, reticular dermis, subcutaneous adipose tissue, and a muscle layer. The formulated boundary-value problem has been solved using the developed in-house computational code based on the finite difference schemes. The developed numerical algorithm has been verified using analytical and numerical solutions of other authors for the simpler test problem. As a result of this study, the temperature distributions have been obtained for the tissue in the presence of tumor zones in different layers of the skin. The influence of five layers of skin on the temperature distribution has been investigated, and the dependence for the skin surface temperature on the tumor zone location has been obtained. The obtained outcomes illustrate the effectiveness of this technique of cancer diagnosis and identify the optimal parameters for its application. Thus, this work represents an important step in the development of cancer diagnosis methods using thermography. The results obtained can be used to improve the accuracy of diagnosis and develop new treatment methods. |
| first_indexed | 2024-04-25T00:24:16Z |
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| id | doaj.art-51585b474e4646fb998a3d1213ce488a |
| institution | Directory Open Access Journal |
| issn | 2227-7390 |
| language | English |
| last_indexed | 2024-04-25T00:24:16Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematics |
| spelling | doaj.art-51585b474e4646fb998a3d1213ce488a2024-03-12T16:49:55ZengMDPI AGMathematics2227-73902024-02-0112567610.3390/math12050676Mathematical Simulation of Bio-Heat Transfer in Tissues Having Five Layers in the Presence of a Tumor ZoneDayana V. Akulova0Mikhail A. Sheremet1Department of Theoretical Mechanics, Tomsk State University, 634050 Tomsk, RussiaDepartment of Theoretical Mechanics, Tomsk State University, 634050 Tomsk, RussiaA presence of tumor zones within biological tissues can be defined during the analysis of the skin surface temperature. This research is devoted to mathematical simulation of the time-dependent bio-heat transfer in tissues under a tumor influence. The one-dimensional partial differential equation of the Pennes model has been used for description of bio-heat transfer within the biological tissue with five layers, namely, epidermis, papillary dermis, reticular dermis, subcutaneous adipose tissue, and a muscle layer. The formulated boundary-value problem has been solved using the developed in-house computational code based on the finite difference schemes. The developed numerical algorithm has been verified using analytical and numerical solutions of other authors for the simpler test problem. As a result of this study, the temperature distributions have been obtained for the tissue in the presence of tumor zones in different layers of the skin. The influence of five layers of skin on the temperature distribution has been investigated, and the dependence for the skin surface temperature on the tumor zone location has been obtained. The obtained outcomes illustrate the effectiveness of this technique of cancer diagnosis and identify the optimal parameters for its application. Thus, this work represents an important step in the development of cancer diagnosis methods using thermography. The results obtained can be used to improve the accuracy of diagnosis and develop new treatment methods.https://www.mdpi.com/2227-7390/12/5/676bio-heat transfertissuefive skin layerstumorPennes modelnumerical simulation |
| spellingShingle | Dayana V. Akulova Mikhail A. Sheremet Mathematical Simulation of Bio-Heat Transfer in Tissues Having Five Layers in the Presence of a Tumor Zone Mathematics bio-heat transfer tissue five skin layers tumor Pennes model numerical simulation |
| title | Mathematical Simulation of Bio-Heat Transfer in Tissues Having Five Layers in the Presence of a Tumor Zone |
| title_full | Mathematical Simulation of Bio-Heat Transfer in Tissues Having Five Layers in the Presence of a Tumor Zone |
| title_fullStr | Mathematical Simulation of Bio-Heat Transfer in Tissues Having Five Layers in the Presence of a Tumor Zone |
| title_full_unstemmed | Mathematical Simulation of Bio-Heat Transfer in Tissues Having Five Layers in the Presence of a Tumor Zone |
| title_short | Mathematical Simulation of Bio-Heat Transfer in Tissues Having Five Layers in the Presence of a Tumor Zone |
| title_sort | mathematical simulation of bio heat transfer in tissues having five layers in the presence of a tumor zone |
| topic | bio-heat transfer tissue five skin layers tumor Pennes model numerical simulation |
| url | https://www.mdpi.com/2227-7390/12/5/676 |
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