Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation
Histones, the major protein components of chromatin, are released into the extracellular space during sepsis, trauma, and ischemia-reperfusion injury, and subsequently mediate organ failure. Extracellular histones can promote endothelial damage and platelet aggregation, which can be suppressed by ad...
Main Authors: | Binita Shrestha, Takashi Ito, Midori Kakuuchi, Takaaki Totoki, Tomoka Nagasato, Mika Yamamoto, Ikuro Maruyama |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-10-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02535/full |
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