Characterization of primary visual cortex input to specific cell types in the superior colliculus
The superior colliculus is a critical brain region involved in processing visual information. It receives visual input directly from the retina, as well as via a projection from primary visual cortex. Here we determine which cell types in the superficial superior colliculus receive visual input from...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Neuroanatomy |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnana.2023.1282941/full |
| _version_ | 1827586465815592960 |
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| author | Shuang Jiang Suraj Honnuraiah Greg J. Stuart Greg J. Stuart |
| author_facet | Shuang Jiang Suraj Honnuraiah Greg J. Stuart Greg J. Stuart |
| author_sort | Shuang Jiang |
| collection | DOAJ |
| description | The superior colliculus is a critical brain region involved in processing visual information. It receives visual input directly from the retina, as well as via a projection from primary visual cortex. Here we determine which cell types in the superficial superior colliculus receive visual input from primary visual cortex in mice. Neurons in the superficial layers of the superior colliculus were classified into four groups – Wide-field, narrow-field, horizontal and stellate – based on their morphological and electrophysiological properties. To determine functional connections between V1 and these four different cell types we expressed Channelrhodopsin2 in primary visual cortex and then optically stimulated these axons while recording from different neurons in the superficial superior colliculus using whole-cell patch-clamp recording in vitro. We found that all four cell types in the superficial layers of the superior colliculus received monosynaptic (direct) input from V1. Wide-field neurons were more likely than other cell types to receive primary visual cortex input. Our results provide information on the cell specificity of the primary visual cortex to superior colliculus projection, increasing our understanding of how visual information is processed in the superior colliculus at the single cell level. |
| first_indexed | 2024-03-09T00:01:57Z |
| format | Article |
| id | doaj.art-515940121fd64b4cbb793a9e2ebe4907 |
| institution | Directory Open Access Journal |
| issn | 1662-5129 |
| language | English |
| last_indexed | 2024-03-09T00:01:57Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroanatomy |
| spelling | doaj.art-515940121fd64b4cbb793a9e2ebe49072023-12-12T16:39:19ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292023-11-011710.3389/fnana.2023.12829411282941Characterization of primary visual cortex input to specific cell types in the superior colliculusShuang Jiang0Suraj Honnuraiah1Greg J. Stuart2Greg J. Stuart3Eccles Institute for Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, AustraliaEccles Institute for Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, AustraliaEccles Institute for Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, AustraliaDepartment of Physiology, Monash University, Clayton, VIC, AustraliaThe superior colliculus is a critical brain region involved in processing visual information. It receives visual input directly from the retina, as well as via a projection from primary visual cortex. Here we determine which cell types in the superficial superior colliculus receive visual input from primary visual cortex in mice. Neurons in the superficial layers of the superior colliculus were classified into four groups – Wide-field, narrow-field, horizontal and stellate – based on their morphological and electrophysiological properties. To determine functional connections between V1 and these four different cell types we expressed Channelrhodopsin2 in primary visual cortex and then optically stimulated these axons while recording from different neurons in the superficial superior colliculus using whole-cell patch-clamp recording in vitro. We found that all four cell types in the superficial layers of the superior colliculus received monosynaptic (direct) input from V1. Wide-field neurons were more likely than other cell types to receive primary visual cortex input. Our results provide information on the cell specificity of the primary visual cortex to superior colliculus projection, increasing our understanding of how visual information is processed in the superior colliculus at the single cell level.https://www.frontiersin.org/articles/10.3389/fnana.2023.1282941/fullsuperior colliculusvisual cortexvisionoptogeneticspatch clamp |
| spellingShingle | Shuang Jiang Suraj Honnuraiah Greg J. Stuart Greg J. Stuart Characterization of primary visual cortex input to specific cell types in the superior colliculus Frontiers in Neuroanatomy superior colliculus visual cortex vision optogenetics patch clamp |
| title | Characterization of primary visual cortex input to specific cell types in the superior colliculus |
| title_full | Characterization of primary visual cortex input to specific cell types in the superior colliculus |
| title_fullStr | Characterization of primary visual cortex input to specific cell types in the superior colliculus |
| title_full_unstemmed | Characterization of primary visual cortex input to specific cell types in the superior colliculus |
| title_short | Characterization of primary visual cortex input to specific cell types in the superior colliculus |
| title_sort | characterization of primary visual cortex input to specific cell types in the superior colliculus |
| topic | superior colliculus visual cortex vision optogenetics patch clamp |
| url | https://www.frontiersin.org/articles/10.3389/fnana.2023.1282941/full |
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