Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study
The relationship between newly diagnosed acute leukemia (AL) and heart-related lesions remains unclear. This study aimed to investigate baseline cardiac function and risk of cardiovascular diseases (CVDs) in patients with new-onset AL, and provide data on cardiac management strategies for patients w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.844350/full |
| _version_ | 1828327672486297600 |
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| author | Wei Xiao Linlu Ma Yufeng Shang Fuwei Yang Yuxin Tan Guopeng Chen Jinxian Wu Yuxing Liang Tuerxunayi Rouzi Qian Wang Nan Zhang Fuling Zhou |
| author_facet | Wei Xiao Linlu Ma Yufeng Shang Fuwei Yang Yuxin Tan Guopeng Chen Jinxian Wu Yuxing Liang Tuerxunayi Rouzi Qian Wang Nan Zhang Fuling Zhou |
| author_sort | Wei Xiao |
| collection | DOAJ |
| description | The relationship between newly diagnosed acute leukemia (AL) and heart-related lesions remains unclear. This study aimed to investigate baseline cardiac function and risk of cardiovascular diseases (CVDs) in patients with new-onset AL, and provide data on cardiac management strategies for patients with AL. We retrospectively collected data on baseline characteristics, echocardiography, and biochemical blood indicators (e.g., myocardial enzymes) from 408 patients, 200 with newly diagnosed AL, 103 with coronary artery disease (CAD), and 105 controls from January 1, 2015 to August 31, 2019. The creatine kinase isoenzyme myocardial band, lactate dehydrogenase, highly sensitive troponin-I, and B-type natriuretic peptide levels and left ventricular internal diameter (LVID) were significantly higher in patients with newly diagnosed AL than in the control group. The degree of cardiac damage was lower in newly diagnosed AL patients than in CAD patients. The best predictor of heart damage was LVID (AUC [area under the curve] = 0.709; 95% CI [confidence interval]: 0.637–0.781; p < 0.001), and independent prognostic risk factors were age and ejection fraction (HR [hazard ratio] = 1.636; 95% CI: 1.039–2.575; p = 0.033). The ratio of leukemia blasts among patients with AL was positively correlated with cardiac damage. Our data indicated that newly diagnosed AL patients had certain myocardial damage before treatment. Clinicians need to pay attention to these manifestations, which may be related to the prognosis. |
| first_indexed | 2024-04-13T19:58:14Z |
| format | Article |
| id | doaj.art-515980138d4545bb9d08cd091bfd579f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T19:58:14Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-515980138d4545bb9d08cd091bfd579f2022-12-22T02:32:16ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.844350844350Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World StudyWei XiaoLinlu MaYufeng ShangFuwei YangYuxin TanGuopeng ChenJinxian WuYuxing LiangTuerxunayi RouziQian WangNan ZhangFuling ZhouThe relationship between newly diagnosed acute leukemia (AL) and heart-related lesions remains unclear. This study aimed to investigate baseline cardiac function and risk of cardiovascular diseases (CVDs) in patients with new-onset AL, and provide data on cardiac management strategies for patients with AL. We retrospectively collected data on baseline characteristics, echocardiography, and biochemical blood indicators (e.g., myocardial enzymes) from 408 patients, 200 with newly diagnosed AL, 103 with coronary artery disease (CAD), and 105 controls from January 1, 2015 to August 31, 2019. The creatine kinase isoenzyme myocardial band, lactate dehydrogenase, highly sensitive troponin-I, and B-type natriuretic peptide levels and left ventricular internal diameter (LVID) were significantly higher in patients with newly diagnosed AL than in the control group. The degree of cardiac damage was lower in newly diagnosed AL patients than in CAD patients. The best predictor of heart damage was LVID (AUC [area under the curve] = 0.709; 95% CI [confidence interval]: 0.637–0.781; p < 0.001), and independent prognostic risk factors were age and ejection fraction (HR [hazard ratio] = 1.636; 95% CI: 1.039–2.575; p = 0.033). The ratio of leukemia blasts among patients with AL was positively correlated with cardiac damage. Our data indicated that newly diagnosed AL patients had certain myocardial damage before treatment. Clinicians need to pay attention to these manifestations, which may be related to the prognosis.https://www.frontiersin.org/articles/10.3389/fmed.2022.844350/fullacute leukemiacardiac damagehyperleukocytic leukemiamyocardial enzymeechocardiography |
| spellingShingle | Wei Xiao Linlu Ma Yufeng Shang Fuwei Yang Yuxin Tan Guopeng Chen Jinxian Wu Yuxing Liang Tuerxunayi Rouzi Qian Wang Nan Zhang Fuling Zhou Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study Frontiers in Medicine acute leukemia cardiac damage hyperleukocytic leukemia myocardial enzyme echocardiography |
| title | Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study |
| title_full | Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study |
| title_fullStr | Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study |
| title_full_unstemmed | Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study |
| title_short | Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study |
| title_sort | cardiac related lesions in newly diagnosed patients with acute leukemia a chinese population based real world study |
| topic | acute leukemia cardiac damage hyperleukocytic leukemia myocardial enzyme echocardiography |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.844350/full |
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