Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma
Abstract Colorectal cancer (CRC) and hepatocellular carcinoma (HCC) are the second and third most common causes of death by cancer, respectively. The etiologies of the two cancers are either infectious insult or due to chronic use of alcohol, smoking, diet, obesity and diabetes. Pathological changes...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Oxford University Press
2020-08-01
|
| Series: | Protein & Cell |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s13238-020-00748-0 |
| _version_ | 1827831183480717312 |
|---|---|
| author | Wei Jia Cynthia Rajani Hongxi Xu Xiaojiao Zheng |
| author_facet | Wei Jia Cynthia Rajani Hongxi Xu Xiaojiao Zheng |
| author_sort | Wei Jia |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) and hepatocellular carcinoma (HCC) are the second and third most common causes of death by cancer, respectively. The etiologies of the two cancers are either infectious insult or due to chronic use of alcohol, smoking, diet, obesity and diabetes. Pathological changes in the composition of the gut microbiota that lead to intestinal inflammation are a common factor for both HCC and CRC. However, the gut microbiota of the cancer patient evolves with disease pathogenesis in unique ways that are affected by etiologies and environmental factors. In this review, we examine the changes that occur in the composition of the gut microbiota across the stages of the HCC and CRC. Based on the idea that the gut microbiota are an additional “lifeline” and contribute to the tumor microenvironment, we can observe from previously published literature how the microbiota can cause a shift in the balance from normal → inflammation → diminished inflammation from early to later disease stages. This pattern leads to the hypothesis that tumor survival depends on a less pro-inflammatory tumor microenvironment. The differences observed in the gut microbiota composition between different disease etiologies as well as between HCC and CRC suggest that the tumor microenvironment is unique for each case. |
| first_indexed | 2024-03-12T04:40:55Z |
| format | Article |
| id | doaj.art-515a709ab0a84e7083532067e5b288ab |
| institution | Directory Open Access Journal |
| issn | 1674-800X 1674-8018 |
| language | English |
| last_indexed | 2024-03-12T04:40:55Z |
| publishDate | 2020-08-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | Protein & Cell |
| spelling | doaj.art-515a709ab0a84e7083532067e5b288ab2023-09-03T09:39:17ZengOxford University PressProtein & Cell1674-800X1674-80182020-08-0112537439310.1007/s13238-020-00748-0Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinomaWei Jia0Cynthia Rajani1Hongxi Xu2Xiaojiao Zheng3Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalUniversity of Hawaii Cancer CenterSchool of Pharmacy, Shanghai University of Traditional Chinese MedicineCenter for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s HospitalAbstract Colorectal cancer (CRC) and hepatocellular carcinoma (HCC) are the second and third most common causes of death by cancer, respectively. The etiologies of the two cancers are either infectious insult or due to chronic use of alcohol, smoking, diet, obesity and diabetes. Pathological changes in the composition of the gut microbiota that lead to intestinal inflammation are a common factor for both HCC and CRC. However, the gut microbiota of the cancer patient evolves with disease pathogenesis in unique ways that are affected by etiologies and environmental factors. In this review, we examine the changes that occur in the composition of the gut microbiota across the stages of the HCC and CRC. Based on the idea that the gut microbiota are an additional “lifeline” and contribute to the tumor microenvironment, we can observe from previously published literature how the microbiota can cause a shift in the balance from normal → inflammation → diminished inflammation from early to later disease stages. This pattern leads to the hypothesis that tumor survival depends on a less pro-inflammatory tumor microenvironment. The differences observed in the gut microbiota composition between different disease etiologies as well as between HCC and CRC suggest that the tumor microenvironment is unique for each case.https://doi.org/10.1007/s13238-020-00748-0gut microbiotacolorectal cancerhepatocellular carcinoma |
| spellingShingle | Wei Jia Cynthia Rajani Hongxi Xu Xiaojiao Zheng Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma Protein & Cell gut microbiota colorectal cancer hepatocellular carcinoma |
| title | Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma |
| title_full | Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma |
| title_fullStr | Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma |
| title_full_unstemmed | Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma |
| title_short | Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma |
| title_sort | gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma |
| topic | gut microbiota colorectal cancer hepatocellular carcinoma |
| url | https://doi.org/10.1007/s13238-020-00748-0 |
| work_keys_str_mv | AT weijia gutmicrobiotaalterationsaredistinctforprimarycolorectalcancerandhepatocellularcarcinoma AT cynthiarajani gutmicrobiotaalterationsaredistinctforprimarycolorectalcancerandhepatocellularcarcinoma AT hongxixu gutmicrobiotaalterationsaredistinctforprimarycolorectalcancerandhepatocellularcarcinoma AT xiaojiaozheng gutmicrobiotaalterationsaredistinctforprimarycolorectalcancerandhepatocellularcarcinoma |