Origins and functions of eosinophils in two non-mucosal tissues
Eosinophils are a type of granulocyte named after the presence of their eosin-stained granules. Traditionally, eosinophils have been best known to play prominent roles in anti-parasitic responses and mediating allergic reactions. Knowledge of their behaviour has expanded with time, and they are now...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368142/full |
| _version_ | 1797249274991345664 |
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| author | Katie S. Day Katie S. Day Lucas Rempel Fabio M. V. Rossi Marine Theret |
| author_facet | Katie S. Day Katie S. Day Lucas Rempel Fabio M. V. Rossi Marine Theret |
| author_sort | Katie S. Day |
| collection | DOAJ |
| description | Eosinophils are a type of granulocyte named after the presence of their eosin-stained granules. Traditionally, eosinophils have been best known to play prominent roles in anti-parasitic responses and mediating allergic reactions. Knowledge of their behaviour has expanded with time, and they are now recognized to play integral parts in the homeostasis of gastrointestinal, respiratory, skeletal muscle, adipose, and connective tissue systems. As such, they are implicated in a myriad of pathologies, and have been the target of several medical therapies. This review focuses on the lifespan of eosinophils, from their origins in the bone marrow, to their tissue-resident role. In particular, we wish to highlight the functions of eosinophils in non-mucosal tissues with skeletal muscle and the adipose tissues as examples, and to discuss the current understanding of their participation in diseased states in these tissues. |
| first_indexed | 2024-04-24T20:27:53Z |
| format | Article |
| id | doaj.art-515b5648005448688391fee99d69c73f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-24T20:27:53Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-515b5648005448688391fee99d69c73f2024-03-22T04:20:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-03-011510.3389/fimmu.2024.13681421368142Origins and functions of eosinophils in two non-mucosal tissuesKatie S. Day0Katie S. Day1Lucas Rempel2Fabio M. V. Rossi3Marine Theret4Department of Medical Genetics, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, CanadaDepartment of Biology and Biochemistry, University of Bath, Bath, United KingdomDepartment of Medical Genetics, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, CanadaDepartment of Medical Genetics, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, CanadaDepartment of Medical Genetics, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, CanadaEosinophils are a type of granulocyte named after the presence of their eosin-stained granules. Traditionally, eosinophils have been best known to play prominent roles in anti-parasitic responses and mediating allergic reactions. Knowledge of their behaviour has expanded with time, and they are now recognized to play integral parts in the homeostasis of gastrointestinal, respiratory, skeletal muscle, adipose, and connective tissue systems. As such, they are implicated in a myriad of pathologies, and have been the target of several medical therapies. This review focuses on the lifespan of eosinophils, from their origins in the bone marrow, to their tissue-resident role. In particular, we wish to highlight the functions of eosinophils in non-mucosal tissues with skeletal muscle and the adipose tissues as examples, and to discuss the current understanding of their participation in diseased states in these tissues.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368142/fullskeletal muscletissue repairimmune cellsadipose tissueeosinophil |
| spellingShingle | Katie S. Day Katie S. Day Lucas Rempel Fabio M. V. Rossi Marine Theret Origins and functions of eosinophils in two non-mucosal tissues Frontiers in Immunology skeletal muscle tissue repair immune cells adipose tissue eosinophil |
| title | Origins and functions of eosinophils in two non-mucosal tissues |
| title_full | Origins and functions of eosinophils in two non-mucosal tissues |
| title_fullStr | Origins and functions of eosinophils in two non-mucosal tissues |
| title_full_unstemmed | Origins and functions of eosinophils in two non-mucosal tissues |
| title_short | Origins and functions of eosinophils in two non-mucosal tissues |
| title_sort | origins and functions of eosinophils in two non mucosal tissues |
| topic | skeletal muscle tissue repair immune cells adipose tissue eosinophil |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1368142/full |
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