Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of glioma
Glioblastoma multiforme (GBM) is the most common glial tumor of the brain system; nevertheless, the giant cell (GC) subtype is uncommon. Recent reviews report for an incidence of 1% in adults and 3% in children. The GCs usually have a better prognosis than GBM and also an increasing long-term surviv...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2015-03-01
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| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/5634 |
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| author | Telmo A.B. Belsuzarri João F.M. Araujo Aguinaldo P. Catanoce Maick W.F. Neves Rodrigo A.S. Sola Juliano N. Navarro Leandro G. Brito Nilton R. Silva Junior Luis Otavio C. Pontelli Luiz Gustavo A. Mattos Tiago F. Gonçales Wolnei M. Zeviani Renata M.B. Marques |
| author_facet | Telmo A.B. Belsuzarri João F.M. Araujo Aguinaldo P. Catanoce Maick W.F. Neves Rodrigo A.S. Sola Juliano N. Navarro Leandro G. Brito Nilton R. Silva Junior Luis Otavio C. Pontelli Luiz Gustavo A. Mattos Tiago F. Gonçales Wolnei M. Zeviani Renata M.B. Marques |
| author_sort | Telmo A.B. Belsuzarri |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is the most common glial tumor of the brain system; nevertheless, the giant cell (GC) subtype is uncommon. Recent reviews report for an incidence of 1% in adults and 3% in children. The GCs usually have a better prognosis than GBM and also an increasing long-term survival rate. It is known that the diagnosis of this tumor is due to its histological findings and patterns, such as the unusual increased number of giant cells. Unfortunately, due to its rarity, the immunohistochemical and cytogenetical analysis of this tumor is not well known. Some authors also suggest that there are few subtypes of GCs and their patterns of aggressiveness could be due to cytogenetical markers. It is recognized that maximum safe resection treatment and adjuvant radiotherapy can improve survival rate (5-13 months) similar to GBM patients. |
| first_indexed | 2024-12-20T13:44:20Z |
| format | Article |
| id | doaj.art-515f5f5c5c514649a4bc7ad0119062b8 |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-20T13:44:20Z |
| publishDate | 2015-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-515f5f5c5c514649a4bc7ad0119062b82022-12-21T19:38:44ZengSAGE PublishingRare Tumors2036-36052036-36132015-03-017110.4081/rt.2015.56343046Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of gliomaTelmo A.B. Belsuzarri0João F.M. Araujo1Aguinaldo P. Catanoce2Maick W.F. Neves3Rodrigo A.S. Sola4Juliano N. Navarro5Leandro G. Brito6Nilton R. Silva Junior7Luis Otavio C. Pontelli8Luiz Gustavo A. Mattos9Tiago F. Gonçales10Wolnei M. Zeviani11Renata M.B. Marques12Department of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Neurosurgery, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloDepartment of Pathology, Maternity Hospital of Celso Pierro, Pontifical Catholic University of Campinas, São PauloGlioblastoma multiforme (GBM) is the most common glial tumor of the brain system; nevertheless, the giant cell (GC) subtype is uncommon. Recent reviews report for an incidence of 1% in adults and 3% in children. The GCs usually have a better prognosis than GBM and also an increasing long-term survival rate. It is known that the diagnosis of this tumor is due to its histological findings and patterns, such as the unusual increased number of giant cells. Unfortunately, due to its rarity, the immunohistochemical and cytogenetical analysis of this tumor is not well known. Some authors also suggest that there are few subtypes of GCs and their patterns of aggressiveness could be due to cytogenetical markers. It is recognized that maximum safe resection treatment and adjuvant radiotherapy can improve survival rate (5-13 months) similar to GBM patients.http://www.pagepress.org/journals/index.php/rt/article/view/5634glioblastoma multiforme, giant cell glioblastoma, genetic, immunohistochemical, long-term survival |
| spellingShingle | Telmo A.B. Belsuzarri João F.M. Araujo Aguinaldo P. Catanoce Maick W.F. Neves Rodrigo A.S. Sola Juliano N. Navarro Leandro G. Brito Nilton R. Silva Junior Luis Otavio C. Pontelli Luiz Gustavo A. Mattos Tiago F. Gonçales Wolnei M. Zeviani Renata M.B. Marques Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of glioma Rare Tumors glioblastoma multiforme, giant cell glioblastoma, genetic, immunohistochemical, long-term survival |
| title | Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of glioma |
| title_full | Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of glioma |
| title_fullStr | Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of glioma |
| title_full_unstemmed | Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of glioma |
| title_short | Giant cells glioblastoma: case report and pathological analysis from this uncommon subtype of glioma |
| title_sort | giant cells glioblastoma case report and pathological analysis from this uncommon subtype of glioma |
| topic | glioblastoma multiforme, giant cell glioblastoma, genetic, immunohistochemical, long-term survival |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/5634 |
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