PEDF inhibits LPS-induced acute lung injury in rats and promotes lung epithelial cell survival by upregulating PPAR-γ

PEDF inhibits LPS-induced acute lung injury in rats and promotes lung epithelial cell survival by upregulating PPAR-γ

Abstract Background The progression of acute lung injury (ALI) involves numerous pathological factors and complex mechanisms, and cause the destruction of epithelial and endothelial barriers. Pigment epithelium-derived factor (PEDF) is an angiogenesis inhibitor and a potential anti-inflammatory fact...

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Bibliographic Details
Main Authors: Lei Xu, Yifei Chen, Shoujie Feng, Zeyan Liu, Ying Ye, Ranran Zhou, Lijun Liu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Pulmonary Medicine
Subjects:
PEDF
ALI
Anti-inflammatory
Epithelial cell
PPAR-γ
Online Access:https://doi.org/10.1186/s12890-023-02666-3

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