Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments

Caldesmon controls stress fiber force-balance through dynamic cross-linking of myosin II and actin-tropomyosin filaments

In this study the authors report that Caldesmon controls force-balance and architecture of stress fibers through dynamic cross-linking of actin and myosin filaments. Caldesmon depletion led to consequent problems in cell morphogenesis, motility and mechanosensing.

Bibliographic Details
Main Authors: Shrikant B. Kokate, Katarzyna Ciuba, Vivien D. Tran, Reena Kumari, Sari Tojkander, Ulrike Engel, Konstantin Kogan, Sanjay Kumar, Pekka Lappalainen
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33688-w

Internet

https://doi.org/10.1038/s41467-022-33688-w

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