Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents
The solubility parameters, and solution thermodynamics of temozolomide (TMZ) in 10 frequently used solvents were examined at five different temperatures. The maximum mole fraction solubility of TMZ was ascertained in dimethyl sulfoxide (1.35 × 10<sup>−2</sup>), followed by that in polyet...
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MDPI AG
2022-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/4/1437 |
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| author | Abdul Ahad Faiyaz Shakeel Mohammad Raish Ajaz Ahmad Yousef A. Bin Jardan Fahad I. Al-Jenoobi Abdullah M. Al-Mohizea |
| author_facet | Abdul Ahad Faiyaz Shakeel Mohammad Raish Ajaz Ahmad Yousef A. Bin Jardan Fahad I. Al-Jenoobi Abdullah M. Al-Mohizea |
| author_sort | Abdul Ahad |
| collection | DOAJ |
| description | The solubility parameters, and solution thermodynamics of temozolomide (TMZ) in 10 frequently used solvents were examined at five different temperatures. The maximum mole fraction solubility of TMZ was ascertained in dimethyl sulfoxide (1.35 × 10<sup>−2</sup>), followed by that in polyethylene glycol-400 (3.32 × 10<sup>−3</sup>) > Transcutol<sup>®</sup> (2.89 × 10<sup>−3</sup>) > ethylene glycol (1.64 × 10<sup>−3</sup>) > propylene glycol (1.47 × 10<sup>−3</sup>) > H<sub>2</sub>O (7.70 × 10<sup>−4</sup>) > ethyl acetate (5.44 × 10<sup>−4</sup>) > ethanol (1.80 × 10<sup>−4</sup>) > isopropyl alcohol (1.32 × 10<sup>−4</sup>) > 1-butanol (1.07 × 10<sup>−4</sup>) at 323.2 K. An analogous pattern was also observed for the other investigated temperatures. The quantitated TMZ solubility values were regressed using Apelblat and Van’t Hoff models and showed overall deviances of 0.96% and 1.33%, respectively. Apparent thermodynamic analysis indicated endothermic, spontaneous, and entropy-driven dissolution of TMZ in all solvents. TMZ solubility data may help to formulate dosage forms, recrystallize, purify, and extract/separate TMZ. |
| first_indexed | 2024-03-09T21:19:40Z |
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| last_indexed | 2024-03-09T21:19:40Z |
| publishDate | 2022-02-01 |
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| series | Molecules |
| spelling | doaj.art-5162c4cbca7b460585e5cfb8c43716bc2023-11-23T21:23:58ZengMDPI AGMolecules1420-30492022-02-01274143710.3390/molecules27041437Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical SolventsAbdul Ahad0Faiyaz Shakeel1Mohammad Raish2Ajaz Ahmad3Yousef A. Bin Jardan4Fahad I. Al-Jenoobi5Abdullah M. Al-Mohizea6Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaThe solubility parameters, and solution thermodynamics of temozolomide (TMZ) in 10 frequently used solvents were examined at five different temperatures. The maximum mole fraction solubility of TMZ was ascertained in dimethyl sulfoxide (1.35 × 10<sup>−2</sup>), followed by that in polyethylene glycol-400 (3.32 × 10<sup>−3</sup>) > Transcutol<sup>®</sup> (2.89 × 10<sup>−3</sup>) > ethylene glycol (1.64 × 10<sup>−3</sup>) > propylene glycol (1.47 × 10<sup>−3</sup>) > H<sub>2</sub>O (7.70 × 10<sup>−4</sup>) > ethyl acetate (5.44 × 10<sup>−4</sup>) > ethanol (1.80 × 10<sup>−4</sup>) > isopropyl alcohol (1.32 × 10<sup>−4</sup>) > 1-butanol (1.07 × 10<sup>−4</sup>) at 323.2 K. An analogous pattern was also observed for the other investigated temperatures. The quantitated TMZ solubility values were regressed using Apelblat and Van’t Hoff models and showed overall deviances of 0.96% and 1.33%, respectively. Apparent thermodynamic analysis indicated endothermic, spontaneous, and entropy-driven dissolution of TMZ in all solvents. TMZ solubility data may help to formulate dosage forms, recrystallize, purify, and extract/separate TMZ.https://www.mdpi.com/1420-3049/27/4/1437Apelblat and Van’t Hoff modelssolubilitysolution thermodynamicstemozolomide |
| spellingShingle | Abdul Ahad Faiyaz Shakeel Mohammad Raish Ajaz Ahmad Yousef A. Bin Jardan Fahad I. Al-Jenoobi Abdullah M. Al-Mohizea Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents Molecules Apelblat and Van’t Hoff models solubility solution thermodynamics temozolomide |
| title | Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents |
| title_full | Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents |
| title_fullStr | Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents |
| title_full_unstemmed | Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents |
| title_short | Thermodynamic Solubility Profile of Temozolomide in Different Commonly Used Pharmaceutical Solvents |
| title_sort | thermodynamic solubility profile of temozolomide in different commonly used pharmaceutical solvents |
| topic | Apelblat and Van’t Hoff models solubility solution thermodynamics temozolomide |
| url | https://www.mdpi.com/1420-3049/27/4/1437 |
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