Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics
Chitosan (CS) is a linear polysaccharide with good biodegradability, biocompatibility and antimicrobial activity, which makes it potentially useful for biomedical applications, including an antimicrobial agent either alone or blended with other polymers. However, the poor solubility of CS in most so...
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| Format: | Article |
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MDPI AG
2013-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/14/1/1854 |
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| author | Ziwei Liu Tingting Tang Chucheng Lin Rui Ma Honglue Tan |
| author_facet | Ziwei Liu Tingting Tang Chucheng Lin Rui Ma Honglue Tan |
| author_sort | Ziwei Liu |
| collection | DOAJ |
| description | Chitosan (CS) is a linear polysaccharide with good biodegradability, biocompatibility and antimicrobial activity, which makes it potentially useful for biomedical applications, including an antimicrobial agent either alone or blended with other polymers. However, the poor solubility of CS in most solvents at neutral or high pH substantially limits its use. Quaternary ammonium CS, which was prepared by introducing a quaternary ammonium group on a dissociative hydroxyl group or amino group of the CS, exhibited improved water solubility and stronger antibacterial activity relative to CS over an entire range of pH values; thus, this quaternary modification increases the potential biomedical applications of CS in the field of anti-infection. This review discusses the current findings on the antimicrobial properties of quaternized CS synthesized using different methods and the mechanisms of its antimicrobial actions. The potential antimicrobial applications in the orthopedic field and perspectives regarding future studies in this field are also considered. |
| first_indexed | 2024-04-12T03:53:47Z |
| format | Article |
| id | doaj.art-51636f839be147cb87b714cd13c4a7a4 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T03:53:47Z |
| publishDate | 2013-01-01 |
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| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-51636f839be147cb87b714cd13c4a7a42022-12-22T03:48:54ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-01-011411854186910.3390/ijms14011854Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in OrthopedicsZiwei LiuTingting TangChucheng LinRui MaHonglue TanChitosan (CS) is a linear polysaccharide with good biodegradability, biocompatibility and antimicrobial activity, which makes it potentially useful for biomedical applications, including an antimicrobial agent either alone or blended with other polymers. However, the poor solubility of CS in most solvents at neutral or high pH substantially limits its use. Quaternary ammonium CS, which was prepared by introducing a quaternary ammonium group on a dissociative hydroxyl group or amino group of the CS, exhibited improved water solubility and stronger antibacterial activity relative to CS over an entire range of pH values; thus, this quaternary modification increases the potential biomedical applications of CS in the field of anti-infection. This review discusses the current findings on the antimicrobial properties of quaternized CS synthesized using different methods and the mechanisms of its antimicrobial actions. The potential antimicrobial applications in the orthopedic field and perspectives regarding future studies in this field are also considered.http://www.mdpi.com/1422-0067/14/1/1854quaternized CSantimicrobial activitymechanismapplicationorthopedics |
| spellingShingle | Ziwei Liu Tingting Tang Chucheng Lin Rui Ma Honglue Tan Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics International Journal of Molecular Sciences quaternized CS antimicrobial activity mechanism application orthopedics |
| title | Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics |
| title_full | Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics |
| title_fullStr | Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics |
| title_full_unstemmed | Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics |
| title_short | Quaternized Chitosan as an Antimicrobial Agent: Antimicrobial Activity, Mechanism of Action and Biomedical Applications in Orthopedics |
| title_sort | quaternized chitosan as an antimicrobial agent antimicrobial activity mechanism of action and biomedical applications in orthopedics |
| topic | quaternized CS antimicrobial activity mechanism application orthopedics |
| url | http://www.mdpi.com/1422-0067/14/1/1854 |
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