Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats

Spatial Memory Impairment Without Apoptosis Induced by the Combination of Beta-Amyloid Oligomers and Cerebral Ischemia Is Related to Decreased Acetylcholine Release in Rats

The purpose of the present study was to examine the effect of beta-amyloid (Aβ ) oligomers, not the fibrils that make up Aβ plaques, on spatial memory and the cholinergic system in rats. Recently, several researchers have suggested that small assemblies of Aβ, Aβ oligomers, caused memory loss during...

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Bibliographic Details
Main Authors: Takuya Watanabe, Katsunori Iwasaki, Shin Ishikane, Tetsuya Naitou, Yoshitaka Yoshimitsu, Norito Yamagata, Mehmeto Bülent Ozdemir, Kotaro Takasaki, Nobuaki Egashira, Kenichi Mishima, Michihiro Fujiwara
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319315397

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